Protein Info for HP15_2036 in Marinobacter adhaerens HP15

Annotation: Tol-Pal system, TolA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 326 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details TIGR02794: protein TolA" amino acids 2 to 322 (321 residues), 165.8 bits, see alignment E=1.7e-52 PF13103: TonB_2" amino acids 234 to 312 (79 residues), 54.8 bits, see alignment E=1.2e-18 TIGR01352: TonB family C-terminal domain" amino acids 249 to 322 (74 residues), 45.4 bits, see alignment E=7.9e-16 PF03544: TonB_C" amino acids 259 to 321 (63 residues), 31.1 bits, see alignment E=4e-11

Best Hits

KEGG orthology group: K03646, colicin import membrane protein (inferred from 72% identity to maq:Maqu_1700)

Predicted SEED Role

"TolA protein" in subsystem Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PQT0 at UniProt or InterPro

Protein Sequence (326 amino acids)

>HP15_2036 Tol-Pal system, TolA (Marinobacter adhaerens HP15)
MALSVTLHLLILGIALAGWSWTSTDHEPPPRSISARLITQQEPEPSPVVEPVDQQKRDEE
RRAEEQRRKEEAERQRQEEEARRIAEQKRQEEQKRLQQQKEQERQEAEAKEREARKAREA
EAARQKAEAEAKERARQKAEEEKRRQEEAKRKAEEEKRRQEEQRKREEAERKRQEELARQ
EAERKRLEAERKLREQQLEAQAEAAQRAREEESRRQREAAAAKAREAQMLSESEKYQALI
RERLSQAWYPPSSATEEMTARLQITLLPTGELAGVRLVSSSGNTAFDNSALGAVRSLSRY
PIPNDRDTFERYFRQFTIEFNPRRLR