Protein Info for PGA1_c20500 in Phaeobacter inhibens DSM 17395

Annotation: leucine dehydrogenase Ldh

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02812: ELFV_dehydrog_N
  • amino acids 26 to 132 (107 residues), 101.3 bits, E=3.5e-33
• PF00208: ELFV_dehydrog
  • amino acids 217 to 326 (110 residues), 49.5 bits, E=4.9e-17

Best Hits

KEGG orthology group: K00263, leucine dehydrogenase [EC: 1.4.1.9] (inferred from 68% identity to sil:SPO0390)

Predicted SEED Role

"Leucine dehydrogenase (EC 1.4.1.9)" in subsystem Branched-Chain Amino Acid Biosynthesis or Leucine Degradation and HMG-CoA Metabolism (EC 1.4.1.9)

KEGG Metabolic Maps

• Valine, leucine and isoleucine biosynthesis
• Valine, leucine and isoleucine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.9

Sequence Analysis Tools

See I7E1W3 at UniProt or InterPro

Protein Sequence (351 amino acids)

>PGA1_c20500 leucine dehydrogenase Ldh (Phaeobacter inhibens DSM 17395)
MTATLTPVATSTHEEIYRVEDASVGLTGFIAVHSTLLGPAAGGLRMRPYASAEEALTDVK
RLSEGMTYKNAAAGLALGGGKAVIIGDPATQKTPELLRAFARAIDSLDGRYITAEDMGMS
PEDMAILAEETTSVAGLADGEYASGDPSPITARGIFNAIRTAWEHKTGQIDLTDRVVSVQ
GLGHVGWYLCDFLNKAGAKLIVTDVNTAQVTRAVEAFGATAVAPDEIYAVEADIFAPCAI
GGILNSDTIPQLKVALVAGGANNQLASSEDAIALHKRGILYAPDFVANGGGIINVATEIQ
KISNRNSFVADRLEALEVTMAAILAQAAADDVSPDAVAIATVQAKMTPKAA