Protein Info for HP15_1757 in Marinobacter adhaerens HP15

Annotation: electron-transferring-flavoprotein dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 556 PF21162: ETFQO_UQ-bd" amino acids 217 to 311 (95 residues), 136.6 bits, see alignment E=8.7e-44 PF05187: ETF_QO" amino acids 452 to 553 (102 residues), 175.6 bits, see alignment E=5.8e-56

Best Hits

Swiss-Prot: 72% identical to ETFD_PSEAE: Electron transfer flavoprotein-ubiquinone oxidoreductase (PA2953) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00311, electron-transferring-flavoprotein dehydrogenase [EC: 1.5.5.1] (inferred from 94% identity to maq:Maqu_1472)

Predicted SEED Role

"Electron transfer flavoprotein-ubiquinone oxidoreductase (EC 1.5.5.1)" in subsystem Acetyl-CoA fermentation to Butyrate or Anaerobic respiratory reductases (EC 1.5.5.1)

Isozymes

Compare fitness of predicted isozymes for: 1.5.5.1

Use Curated BLAST to search for 1.5.5.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PNM7 at UniProt or InterPro

Protein Sequence (556 amino acids)

>HP15_1757 electron-transferring-flavoprotein dehydrogenase (Marinobacter adhaerens HP15)
MFEETNVERESMEFDVLIVGGGPAGLSAACRVMQLAQEAGEELTVCVVEKGSEIGAHILA
GTVFEPTALTELFPDWKEKGAPLNTPVTRDDIFLLKNQDSATKIPNAFVPKNMHNHGNYI
ISLGNLCRWLAEQAEQLGVEVYPGFAASETIIEDGQVKGIITGDMGVARDGSEKDGYMPG
MELRAKYTLFTEGCRGHLGKRLINEFKLDEGKDPQHYGIGIKELWDIDPAKHEPGLVVHT
TGWPLKETGSTGGSFLYHLENGQVYVGLITDLSYSNPHLSPFEEFQRLKLHPEIKKHLEG
GKRVSYGARAITKGGYNALPKMSFPGGLLLGCDAGTLNGSKIKGSHTAMKSGMLGAEAVF
EALKDGKSGEEISSFQKKFEDSWLFKELYAERNFGPAMHKFGNIVGGAIAYFEQNILRGS
LPITFHDTTPDYATMKPAAECKKVTYPKPDNTLTFDRLSSVFISNTNHEEDQPVHLKLTD
PDLPIRDNLPKYDEPAQRYCPAGVYEVVEKDDGSGKRFQINAQNCVHCKTCDIKDPAQNI
NWVTPEGGGGPNYPNM