Protein Info for HP15_1625 in Marinobacter adhaerens HP15
Annotation: 3-oxoacyl-(acyl carrier protein) synthase III
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 86% identical to FABH_MARHV: 3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
KEGG orthology group: K00648, 3-oxoacyl-[acyl-carrier-protein] synthase III [EC: 2.3.1.180] (inferred from 86% identity to maq:Maqu_1374)MetaCyc: 60% identical to 3-oxoacyl-[acyl carrier protein] synthase 3 (Escherichia coli K-12 substr. MG1655)
[Acyl-carrier-protein] S-acetyltransferase. [EC: 2.3.1.38]; Beta-ketoacyl-acyl-carrier-protein synthase III. [EC: 2.3.1.38, 2.3.1.180]
Predicted SEED Role
"3-oxoacyl-[acyl-carrier-protein] synthase, KASIII (EC 2.3.1.180)" (EC 2.3.1.180)
MetaCyc Pathways
- superpathway of fatty acids biosynthesis (E. coli) (51/53 steps found)
- superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
- superpathway of fatty acid biosynthesis I (E. coli) (16/16 steps found)
- superpathway of fatty acid biosynthesis initiation (5/5 steps found)
- fatty acid biosynthesis initiation (type II) (3/3 steps found)
- fatty acid biosynthesis initiation (mitochondria) (3/4 steps found)
- streptorubin B biosynthesis (20/34 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.3.1.180
Use Curated BLAST to search for 2.3.1.180 or 2.3.1.38
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E4PM61 at UniProt or InterPro
Protein Sequence (322 amino acids)
>HP15_1625 3-oxoacyl-(acyl carrier protein) synthase III (Marinobacter adhaerens HP15) MTFARITGTGSYLPENIVTNKDLEKMVDTTDQWIRERTGIERRHIAVEGQTTVDLAEQAA RNAIDAAGINAQDIDLIVFATSTPDKIFPSSACILQARLGIHGCPAFDIQAVCSGFVYAL ATAEKFIKTGSSKKALVIGAEVFSRIINWEDRGTCVLFGDGAGAVILEADEETGILSTHI HADGQYEDLLHVPCGISDNYDQVKAGRAFVEMKGNEVFKVAVNTLGKIVDETLAANRMQK SEIDWLVPHQANLRIISATAKKLNMSMDQVVVTVNEHGNTSAASIPLALDVAVRDGRIKR NEVLLLEAFGGGFTWGSALLRY