Protein Info for PGA1_c16240 in Phaeobacter inhibens DSM 17395

Annotation: methylthioribose-1-phosphate isomerase MtnA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 65% identical to MTNA_SINMW: Methylthioribose-1-phosphate isomerase (mtnA) from Sinorhizobium medicae (strain WSM419)

KEGG orthology group: K08963, methylthioribose-1-phosphate isomerase [EC: 5.3.1.23] (inferred from 78% identity to dsh:Dshi_0521)

MetaCyc: 62% identical to methylthioribose-1-phosphate isomerase (Escherichia coli ATCC 25922)
S-methyl-5-thioribose-1-phosphate isomerase. [EC: 5.3.1.23]; 5.3.1.23 [EC: 5.3.1.23]

Predicted SEED Role

"Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)" in subsystem Methionine Salvage (EC 5.3.1.23)

MetaCyc Pathways

5'-deoxyadenosine degradation I (3/3 steps found)
S-methyl-5-thio-α-D-ribose 1-phosphate degradation III (3/5 steps found)
5'-deoxyadenosine degradation II (2/4 steps found)
S-methyl-5-thio-α-D-ribose 1-phosphate degradation II (2/5 steps found)
L-methionine salvage cycle III (5/11 steps found)
S-methyl-5-thio-α-D-ribose 1-phosphate degradation I (1/7 steps found)
L-methionine salvage cycle I (bacteria and plants) (4/12 steps found)
L-methionine salvage cycle II (plants) (2/11 steps found)

KEGG Metabolic Maps

Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7E0V9 at UniProt or InterPro

Protein Sequence (367 amino acids)

>PGA1_c16240 methylthioribose-1-phosphate isomerase MtnA (Phaeobacter inhibens DSM 17395)
MKINGTHYRSLWWDEDQSVLMIIDQRWLPHEFRIQPVATLDEFATAIVEMRVRGAPLIGA
TAAYGMALAADLDPSDNALKAAWEQLNATRPTAINLRWALNRCMETLIPLPEEDRAKAAL
KLAHAIADEDVEINRRIGTYGLTLIRDIAVKKPAGEPVRLLTHCNAGWIATVDWGTATSP
MYQAHDAGIPIHVWVDETRPRNQGALTAWELGSHGISHSYITDNAGGHLMQHGQVDLVIT
GTDRTTRQGDVCNKIGTYLKALAAHDNGVPFYVALPSPTIDWTVTDGVAEIPIEDRDSRE
VSHVQGVLDSGDMGLARVTPESTACGNPAFDVTPNRLVTGLITERGICDASAEGLAALFP
DLIRKAG