Protein Info for HP15_1357 in Marinobacter adhaerens HP15

Annotation: gamma-glutamyltranspeptidase periplasmic precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 587 signal peptide" amino acids 1 to 39 (39 residues), see Phobius details TIGR00066: gamma-glutamyltransferase" amino acids 55 to 578 (524 residues), 630 bits, see alignment E=1.4e-193 PF01019: G_glu_transpept" amino acids 70 to 580 (511 residues), 628 bits, see alignment E=7e-193

Best Hits

Swiss-Prot: 50% identical to GGT_PSEUA: Glutathione hydrolase proenzyme (ggt) from Pseudomonas sp. (strain A14)

KEGG orthology group: K00681, gamma-glutamyltranspeptidase [EC: 2.3.2.2] (inferred from 79% identity to maq:Maqu_1019)

Predicted SEED Role

"Gamma-glutamyltranspeptidase (EC 2.3.2.2)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle or Utilization of glutathione as a sulphur source (EC 2.3.2.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.2.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJD5 at UniProt or InterPro

Protein Sequence (587 amino acids)

>HP15_1357 gamma-glutamyltranspeptidase periplasmic precursor (Marinobacter adhaerens HP15)
MDRGLYQRTIKNLATGRPGRLSIAAALAFFITTAPAFGQAILEGERFHPVTATQGMVATS
HTLATEVALEVLKNGGNAIDAAVTAGFALAVTQPRSGNIGGGGFMLISRGDGSDPEAIDY
REKAPAAATETMFQNESGEVVRNRSRFTHLAAGVPGTVAGLALALERHGTITLKQALAPA
IKLAQDGFVVPQRFTEGLEQARERLERWPATRDTFYKEDGSAWQPGERFRQPELAATLQR
IADNGVKGFYEGETADLIASEMERNGGLITHQDLKDYRPVVRAPVHGNYRGYDIFSMSPP
SSGGTHIVQILNILEGFPMAEFGHNSADAIHHMAEAMKLAYADRSKYLGDTDYVEVPLAG
LTSKGYAEELRKGIDPDRARPANDINPGQPAAWESPETTHFSVVDKWGNAVSNTYTINFS
YGSGITVEGAGFLLNNEMDDFSAKPGVPNAYGLIGGEANKVEPGKRMLSSMSPTIVKKDG
KNVLVTGSPGGSRIITTTLQVILNVIDHGMNVQTAVSAPRMHHQWLPDEIRIEQGISPDT
IRLLQERGHTVVGGSAMGAIQSILIDEDGVLNGGADPRRSTSSAMGY