Protein Info for HP15_1352 in Marinobacter adhaerens HP15

Annotation: peptidase S16, lon domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 799 PF20437: LonC_helical" amino acids 88 to 121 (34 residues), 54.5 bits, see alignment (E = 1.8e-18) PF13654: AAA_32" amino acids 309 to 440 (132 residues), 177.6 bits, see alignment E=2.3e-56 PF20436: LonB_AAA-LID" amino acids 468 to 532 (65 residues), 82.3 bits, see alignment E=4e-27 PF05362: Lon_C" amino acids 620 to 745 (126 residues), 31.6 bits, see alignment E=2.5e-11

Best Hits

KEGG orthology group: None (inferred from 59% identity to aeh:Mlg_1517)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type II" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJD0 at UniProt or InterPro

Protein Sequence (799 amino acids)

>HP15_1352 peptidase S16, lon domain protein (Marinobacter adhaerens HP15)
MSLPAPLTENQVYHGCPEDKLDFQTTEDLQDLERPYGQDRVLRALEFGAGIQADGFNLFV
LGPSGAGKHELVERFLCLHAASQPVPPDWCHVYNFQFSERPRAIRLPAGEGRQFKKHMNE
LAEELRTAIPAAFESEEYQARLQELQEEMAKRQHQGLFDIQEEASRNNIAMITTPAGFTF
APMRKGEVIDPEEYKNFSDEEKALVESKVEELQKKLQQTIQQIPRMRKEVRERVHALNEE
MVQLTLGGPIGELREKWSHLQDIVEYLDAVREDVVEHAEAFQDTDNGPPAGLLARYKVNL
LVDNAETAGAPVIYEDLPNHQHLAGQIEHRARQGNLYTDFTLIRGGSMHRASGGYLIIDA
RRVLTQPMAWESLKRILSSGEVRIESLERLYGLVSTVSLQPEPIPVSVKVVLLGDRMLYY
LLSRYDPDFLDLFKVEADFEDDLDRNEECYELYARMIATMARGLKMRPLERSAVARLIEH
ASRLAADQRKLTAHDRVLRDILSEADHWAGQAGADTVEASHLQQAIDEREYRASRVRERS
REQISRGVVMIATTGDEVAQVNGLSVLRLGASMFGQPTRITATARPGKGQVVDIEREAKL
GGPIHSKAVMILSRFLASRYAGDGELSLSASLAFEQSYGGVEGDSASVAETCVLLSAISR
VPIKQAFAVTGSMNQHGEVQAVGGVNEKIEGFFDVCKEAGDVRGQGVLLPASNVEHLMLR
ADVRQAIAEDRFRIYPISSINEAIELLTGLEPGEPDSNGEFPENSFNHRVAERLEKFAEA
SKKRDENGEANSSGGKDRD