Protein Info for PGA1_c13880 in Phaeobacter inhibens DSM 17395

Annotation: putative transporter, BCCT family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 545 transmembrane" amino acids 46 to 65 (20 residues), see Phobius details amino acids 85 to 103 (19 residues), see Phobius details amino acids 123 to 143 (21 residues), see Phobius details amino acids 194 to 213 (20 residues), see Phobius details amino acids 234 to 259 (26 residues), see Phobius details amino acids 275 to 299 (25 residues), see Phobius details amino acids 313 to 342 (30 residues), see Phobius details amino acids 366 to 384 (19 residues), see Phobius details amino acids 395 to 417 (23 residues), see Phobius details amino acids 446 to 465 (20 residues), see Phobius details amino acids 492 to 512 (21 residues), see Phobius details amino acids 518 to 537 (20 residues), see Phobius details PF02028: BCCT" amino acids 46 to 542 (497 residues), 598.6 bits, see alignment E=3.9e-184 TIGR00842: transporter, betaine/carnitine/choline transporter (BCCT) family" amino acids 85 to 543 (459 residues), 465.2 bits, see alignment E=1.1e-143

Best Hits

Swiss-Prot: 69% identical to BCCT2_VIBPA: Glycine betaine/proline/choline transporter VP1723 (VP1723) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K03451, betaine/carnitine transporter, BCCT family (inferred from 79% identity to sit:TM1040_2125)

Predicted SEED Role

"High-affinity choline uptake protein BetT" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EWD5 at UniProt or InterPro

Protein Sequence (545 amino acids)

>PGA1_c13880 putative transporter, BCCT family (Phaeobacter inhibens DSM 17395)
MTDETANQGIPAPDGEAAVIDTEYEIGQDNLEGSVGPIGFDIHNPVFMVSGISIMLFVFY
ALVLPEQAAAFFGWLRPAVTSSFDWFFLSAGNFFVLFCFFLIVSPWGKVRLGGADAAPDY
TYTGWFAMLFAAGMGIGLMFYGVSEPMSHYSTSFGGVSMGENGARTDWAPLGGAAGDSAE
SVRLGMAATIYHWGLHPWAIYAIVALSLALFSFNKGLPLTIRSAFYPIFGERVWGWTGHI
IDILAVFATLFGLATSLGFGATQANAGLNELFGVPVGATTEVVLISAITAVALISVLRGL
DGGVKILSEINMGLAFLLLIFVLLVGPTLLIITGFFDSLLAYVQYLPALSMPFGREDANY
SQGWTAFYWAWWISWSPFVGMFIARVSRGRTVREFIICVLLIPSLVCVLWMSVFGGTAIH
QVVADGYTGAQDTALELKLFKMLDQLPLAAITSFVGILLVIVFFVTSSDSGSLVIDTITA
GGKVDAPMPQRVFWCVFEGAVAIVLLLGGGLVALQAMVISTGLPFTVVLLLMCWAIVRGL
QTETR