Protein Info for PGA1_c01110 in Phaeobacter inhibens DSM 17395

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 561 PF02771: Acyl-CoA_dh_N" amino acids 178 to 289 (112 residues), 114.1 bits, see alignment E=8.9e-37 PF02770: Acyl-CoA_dh_M" amino acids 295 to 396 (102 residues), 68.4 bits, see alignment E=9.9e-23 PF00441: Acyl-CoA_dh_1" amino acids 411 to 560 (150 residues), 148.6 bits, see alignment E=3.1e-47 PF08028: Acyl-CoA_dh_2" amino acids 428 to 546 (119 residues), 48.7 bits, see alignment E=1.9e-16

Best Hits

KEGG orthology group: K14448, (2S)-methylsuccinyl-CoA dehydrogenase (inferred from 88% identity to sil:SPO0693)

Predicted SEED Role

"Methylsuccinyl-CoA dehydrogenase, predicted by (Erb et al, 2007)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7ET77 at UniProt or InterPro

Protein Sequence (561 amino acids)

>PGA1_c01110 acyl-CoA dehydrogenase (Phaeobacter inhibens DSM 17395)
MAHDGQDPQMQPTLISDVLTLTAAALEPVDQLLEAARATVREQVSEDGRVSGALVEAHQT
AAHGLAWLATYAYSLRQMHRWAAQLQADGKFGEMEQLMLQIGFGEYLWQIYGGIQMNQGE
ILRLQDLGLSQDSQRMLMAPAVMTLCDSGNTQAARLRLVELMQDQAGSVMFGASGLDEEL
EMIRDQFRRYALEKVEPNAHDWHLKDELIPMEIIEELAEMGVFGLTIPEEYGGFGLSKAS
MCVVSEELSRGYIGVGSLGTRSEIAAELIIAGGTEEQKASWLPKIASAEILPTAVFTEPN
TGSDLGSLRTRAVKDDNGDYQITGNKTWITHAARTHVMTLLARTDPDTTDHRGLSMFLAE
KTPGTDENPFPTEGMTGGEIEVLGYRGMKEYELGFDGFHVKRENLLGGDEGKGFKQLMET
FESARIQTAARAIGVAQSALDIAMQYAQDRKQFGKPLIAFPRVASKLAMMAVEIMIARQL
TYFSAWEKDNGHRCDLEAGMAKLLGARVAWAAADNGLQIHGGNGFALEYKISRVLCDARI
LNIFEGAAEIQAQVIARRLLA