Protein Info for HP15_994 in Marinobacter adhaerens HP15

Annotation: glycine betaine/carnitine/choline ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 PF00005: ABC_tran" amino acids 18 to 163 (146 residues), 124.7 bits, see alignment E=2.2e-40

Best Hits

Swiss-Prot: 53% identical to YEHX_ECOLI: Glycine betaine uptake system ATP-binding protein YehX (yehX) from Escherichia coli (strain K12)

KEGG orthology group: K05847, osmoprotectant transport system ATP-binding protein (inferred from 60% identity to pmy:Pmen_3117)

MetaCyc: 53% identical to glycine betaine ABC transporter ATP binding subunit YehX (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-283

Predicted SEED Role

"L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PFK9 at UniProt or InterPro

Protein Sequence (315 amino acids)

>HP15_994 glycine betaine/carnitine/choline ABC transporter ATP-binding protein (Marinobacter adhaerens HP15)
MIELKNVTRRFGDAVAVDRINLTVETGEVCVLVGSSGCGKSTTLRMINQLLPHSEGQILV
DGNDVTAMNPEQLRLNMGYVIQGTGLFPHWTVARNIAMVPQLLKWPRERVDERVHELLTL
LDLDPATHANKYPQQLSGGQAQRVGVARALAANPNILLMDEPFGALDAITRENLQLEMLR
IQSQLRKTTVFVTHDIDEALRLATRIAVMDQGRIIQHDTPENILRRPASVFVENLVGKQD
RGLKLMSLHTVRDLMEAHPQPREPEPGADGLKEDDSLRVALSIMLWQNWSQVPVFNADGQ
ETGTITRDRIIQEGA