Protein Info for EX31_RS21805 in Rahnella sp. WP5

Annotation: anti-sigma-E factor RseA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 215 transmembrane" amino acids 98 to 118 (21 residues), see Phobius details PF03872: RseA_N" amino acids 1 to 87 (87 residues), 118.9 bits, see alignment E=1.1e-38 PF03873: RseA_C" amino acids 132 to 185 (54 residues), 82.8 bits, see alignment E=1.6e-27

Best Hits

Swiss-Prot: 68% identical to RSEA_ECOL6: Anti-sigma-E factor RseA (rseA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03597, sigma-E factor negative regulatory protein RseA (inferred from 100% identity to rah:Rahaq_3440)

Predicted SEED Role

"Sigma factor RpoE negative regulatory protein RseA" in subsystem Transcription initiation, bacterial sigma factors

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (215 amino acids)

>EX31_RS21805 anti-sigma-E factor RseA (Rahnella sp. WP5)
MQKEKLSALMDGEAIDTELLSSLSTDTRLQQDWQSYHLIRDTLRGDIGNVVHLDIADRVA
AALANEPVKLVPGSATESQPQPHTWQKMPFWQKVRPWASQLTQVGVAACVSLAVIVGVQH
YNQPDASGASPETPAFNTLPMMGKASPVSFGVPNEGNTTSGQQNVQEQRKRINAMLQDYE
LQRRLHSEQLQLEPVTPQQAAVQVPGTQSLGTQTQ