Protein Info for EX31_RS05995 in Rahnella sp. WP5

Annotation: membrane protein insertase YidC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 544 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 347 to 368 (22 residues), see Phobius details amino acids 414 to 436 (23 residues), see Phobius details amino acids 459 to 477 (19 residues), see Phobius details amino acids 490 to 515 (26 residues), see Phobius details TIGR03593: membrane protein insertase, YidC/Oxa1 family, N-terminal domain" amino acids 3 to 348 (346 residues), 380.6 bits, see alignment E=1.1e-117 PF14849: YidC_periplas" amino acids 61 to 339 (279 residues), 293.4 bits, see alignment E=2.7e-91 TIGR03592: membrane protein insertase, YidC/Oxa1 family" amino acids 349 to 529 (181 residues), 230.1 bits, see alignment E=2.4e-72 PF02096: 60KD_IMP" amino acids 350 to 529 (180 residues), 209.5 bits, see alignment E=3e-66

Best Hits

Swiss-Prot: 84% identical to YIDC_SERP5: Membrane protein insertase YidC (yidC) from Serratia proteamaculans (strain 568)

KEGG orthology group: K03217, preprotein translocase subunit YidC (inferred from 100% identity to rah:Rahaq_4436)

MetaCyc: 76% identical to membrane protein insertase YidC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-403

Predicted SEED Role

"Inner membrane protein translocase component YidC, long form"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (544 amino acids)

>EX31_RS05995 membrane protein insertase YidC (Rahnella sp. WP5)
MDSQRNLFLIALLFVSFMIWQAWQTDHAPQPANQTTQQTANTANGDATNQAVPDSGQGKL
ITVNSDVLSLTINTRGGDIEQALLKAYPTTLGSDQPFQLLETTPNFLYQAQSGLTGKNGP
DNPANGERPLFKASSDTFTMAEGQSELRIPMTYTAANGAIYTKTFVIKRGSYAVNVEYNI
NNTTPAPLELTMFGQLKQTTELPKHRDTGSNNFALHTFRGAAYSSSDDKYQKYAFDKSEA
LNVTTQGGWVAMLQQYFATAWIPSAKDTNTFFTTTNNGISTIGFKGTPFTVAPGAQQQVA
SILWVGPEIQDKMAAIAPHLDLTVDYGWLWFISQPLFKLLKFIQGFVGNWGFSIIVITFI
VRGIMYPLTRAQYTSMAKMRMLQPKLAAMRERIGDDKQRMSQEMMALYKSEKVNPLGGCL
PLVIQMPIFLALYYMLSGSIELRHAPFILWIHDLSAQDPYYILPVLMGITMFFIQKMSPT
TVTDPMQQKIMTFMPVIFTVFFLWFPSGLVVYYIVSNLVTILQQQLIYRGLEKRGLHSRD
KKKS