Protein Info for Dsui_3536 in Dechlorosoma suillum PS

Annotation: leucyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 498 transmembrane" amino acids 375 to 393 (19 residues), see Phobius details PF02789: Peptidase_M17_N" amino acids 19 to 147 (129 residues), 107.8 bits, see alignment E=3.7e-35 PF00883: Peptidase_M17" amino acids 186 to 486 (301 residues), 434.5 bits, see alignment E=2.4e-134

Best Hits

Swiss-Prot: 79% identical to AMPA_DECAR: Probable cytosol aminopeptidase (pepA) from Dechloromonas aromatica (strain RCB)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 79% identity to dar:Daro_3082)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QM17 at UniProt or InterPro

Protein Sequence (498 amino acids)

>Dsui_3536 leucyl aminopeptidase (Dechlorosoma suillum PS)
MEFSIKSGSPEKQRSACVVVGVHEPRKLTLPAELLDNAARSYISDIIRRGDMEGKLGSTL
LLHNVPGTLCDRVLLVGLGKEKEFREKEYCQAVRTAVKTLNETGSFDGVVFLTEIPVKKR
TVSWRVRQAAIVAQETVYRFDQLKSKKDEVRRPLRKLTFAVERRNELTPAEEALNQGLAI
AEGMALAKNLGNLPGNLCTPTYLAEQATAMAQEHGLECQILEKGEMEALGMFSLLSVARG
SHQPPKFIVLQYKGGKKEEKPLVLVGKGITFDTGGISLKPAAEMDEMKYDMCGAASVLGT
IKAAALMKLPVNLTVIVPATENMPGGSATKPGDVVTSLSGQTIEVLNTDAEGRLVLCDAL
TYAERFEPETVIDVATLTGACVVALGAVATGLFSNNDSLARELAHCGDEAFDRAWHMPLW
EDYQELLKSNFADMANIGGRYAGAITAACFLARFTKKFEWAHLDIAGTAWKSGADKGATG
RPVPLLTHYLLKRAGKLD