Protein Info for Dsui_3369 in Dechlorosoma suillum PS

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 17 to 128 (112 residues), 107 bits, E=1.5e-34
• PF02770: Acyl-CoA_dh_M
  • amino acids 132 to 227 (96 residues), 79.8 bits, E=2.8e-26
• PF00441: Acyl-CoA_dh_1
  • amino acids 245 to 385 (141 residues), 106 bits, E=4.2e-34
• PF08028: Acyl-CoA_dh_2
  • amino acids 254 to 374 (121 residues), 29.1 bits, E=2.1e-10

Best Hits

Swiss-Prot: 68% identical to GCDH_HUMAN: Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) from Homo sapiens

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 77% identity to ppu:PP_0158)

MetaCyc: 77% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• glutaryl-CoA degradation (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (3/15 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (3/16 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (3/17 steps found)
• toluene degradation VI (anaerobic) (3/18 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Sequence Analysis Tools

See G8QK20 at UniProt or InterPro

Protein Sequence (394 amino acids)

>Dsui_3369 acyl-CoA dehydrogenase (Dechlorosoma suillum PS)
MSRFNWEDPLQLDDQLSAEERQVRDTARQYSQDRLLPRIVQAFRHEQTDPAIFRELGELG
LLGATLDGYGCAGASYVSYGLLAREIERVDSGYRSMVSVQSSLAMYPIHAFGSEALKERL
LPKMATGELIGCFGLTEPNHGSDPGSMESRAEAVPGGWELTGAKMWITNSPIADVFVVWA
KDGQDEDGGEIRGFVLEKGMKGLSAPVIQGKMGLRASVTGEIVMDKVFVPEENLLPKVKG
LKGPFACLNQARYGIAWGALGAAEACWHAARQYTLDRPQFGRPLAANQLVQKKLADMQTE
IALGLQGCLRLGRLKDEGKDAPEMTSLLKRNSCGKALEIARTARDMHGGNGISDEFHVVR
HMLNLEVVNTYEGTHDIHALILGRAQTGIAAFAN