Protein Info for Dsui_3214 in Dechlorosoma suillum PS

Annotation: ATP-dependent exonuclase V beta subunit, helicase and exonuclease domain-containing

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1113 PF00580: UvrD-helicase" amino acids 14 to 454 (441 residues), 143.2 bits, see alignment E=3.3e-45 PF13245: AAA_19" amino acids 15 to 444 (430 residues), 47.7 bits, see alignment E=4.5e-16 PF13361: UvrD_C" amino acids 781 to 876 (96 residues), 38.4 bits, see alignment E=2.8e-13 PF12705: PDDEXK_1" amino acids 964 to 1097 (134 residues), 23 bits, see alignment E=1.8e-08

Best Hits

Predicted SEED Role

"ATP-dependent DNA helicase pcrA (EC 3.6.1.-)" in subsystem DNA repair, bacterial UvrD and related helicases (EC 3.6.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-

Use Curated BLAST to search for 3.6.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QIT6 at UniProt or InterPro

Protein Sequence (1113 amino acids)

>Dsui_3214 ATP-dependent exonuclase V beta subunit, helicase and exonuclease domain-containing (Dechlorosoma suillum PS)
MTDPRQLVLDALDPRRSVVVEACAGSGKTWLLASRIVRLLLEGAAPGDILAITFTRKAAR
EIEERVMGWLRDLAAMPDAEATVFLAERGMTADAGLLRRARGLYERVADAQPPLSVHTFH
GWFLQLIAAAPLVSGLAGSSLVESTGRLLEELWQNFAAELQADPEGELAGHFTALLQGAG
LDSTRSLLMRLVGRRAEWLAYTGGTENGVAHALEQLQALLGVGEAGEGLKAFFAPGWEAD
YHAYLGFLEQSETKTDQALVAPLRAALQPGAAPEAAFAALGSVLLTQTGTLRSRKPSGAL
DKRFGSDGAARFLDLHQRLGQSLLATREVLRAEQILEFNRHGLSLGAAFLERLEKHKQAR
RLIDFVDAEWQVLQLLQDEGHAAFLQARLDARYKHILLDEFQDTNPLQWQILLAWLDAYT
HGDGGEAPCLFLVGDPKQSIYRFRQAEPRLFATAADFLEHNFGARRLAQDATRRNARSVV
EVVNALFSVEPAFTGFRPQSSLAGQLPGRVELLPLVSLAEEEEQSAGAALRDPLTTPATE
ATDPRRDEEAARLAARLQQFMATLRVKEGEGERPARWGDVMLLVRKRTQLAAYERALKAA
GIPYLAASRGGLLQTLEARDIAALFEFLVLPSADLALAQVLRTPLFAVGDDDLLQLAAAG
PGPWWERLMGLCNRGEARPRLARAFALLDGWLKAADVLPAHDLLDRVFHQGELLARYREA
VPAALWPGVEANLLALLQLALDLDGGRYPSLPRFIDELSRLRDADADEAPDEGIVEGDSN
DGQGRVRILTIHAAKGLEAPIVWLLDANAEGGGPADAWSLLVDWPPQAPRPEHLSLYGIK
ADRGAAREPLFEGEAKLAEREELNLLYVAITRAKQVFVASGSAPKKGDSPENSPYQRLAR
ALVAQGATADEAGTLAYGDLALDAMAGSQAGSQSLPGLPEQWRPAPFLAVEPVGERRLGP
GEDALFGILLHGCLERLTAGLALEPDWWRKVGGATASEAGGEEAEAAARRLMARPELAFL
LDPSLVARNEAEISNAEGQVKRVDRLVETPEAVWVVDYKSSRADTKRLAEYRRQVAEYRE
LLTPLYGQKPVRAALVFGDGTLLEVQEMLSDLG