Protein Info for Dsui_3182 in Dechlorosoma suillum PS

Annotation: hydrophobe/amphiphile efflux-1 (HAE1) family transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1046 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 342 to 361 (20 residues), see Phobius details amino acids 368 to 389 (22 residues), see Phobius details amino acids 395 to 415 (21 residues), see Phobius details amino acids 440 to 462 (23 residues), see Phobius details amino acids 474 to 499 (26 residues), see Phobius details amino acids 541 to 559 (19 residues), see Phobius details amino acids 868 to 887 (20 residues), see Phobius details amino acids 894 to 914 (21 residues), see Phobius details amino acids 920 to 944 (25 residues), see Phobius details amino acids 969 to 989 (21 residues), see Phobius details amino acids 1001 to 1024 (24 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 4 to 1030 (1027 residues), 1409.3 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1023 (1019 residues), 1151.9 bits, see alignment E=0

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 74% identity to azl:AZL_e02620)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QIQ4 at UniProt or InterPro

Protein Sequence (1046 amino acids)

>Dsui_3182 hydrophobe/amphiphile efflux-1 (HAE1) family transporter (Dechlorosoma suillum PS)
MRLPAFFVRRPIFAWVIALFIILLGLIAIPQLPIARYPTVAPPMVSIYAVYPGATPQTMN
DAVVGLIERELSSVKNLLYFESSTDTSGFAQITATFKPGTNPELAQVDVQNRIKTVEPRL
PAVVRQNGLKFESAASSFLMFISLKSDDGRHSEVALNDYMARSMVEELRRVDGVGRVQLF
GSEAAMRIWVDPAKLVAYKLSMSDLSDAVTQQNTQIAPGRVGGAPTVEGQRVTFPVSVQG
QLTTPEQFAAIVLRANPDGSKVVLGDVARVALGAQSYGESNRENGKLAAALGVQMSPGAN
AVRTSAAVKARLAELAKTMPPGMSYSVPFDTAPFVQISIEKVAQTLLEAMLLVFLVMYLF
LQNVRYTFIPAIVAPIALLGTFTVMLATGFSVNVLTMFGMVLAIGIIVDDAIVVVENVER
LMASEGLSPREATLKAMKEISGAVVGITLVLIAVFIPMALAGGSVGVIYRQFTLSMAVSI
LFSAFLALTLTPALCATLLKPVDGAHHEKGGFFGWFNRMFERMTGRYETRVVAMVRRSGR
AMAVFLAITGVLALGFWQLPSAFLPEEDQGYFITSIQLPSDATTERTLDVVKAFEAHAVG
RPGIEAVQAVLGWGFSGSGPNAAIIFTTLKEWHERQGATAPAEVMAAQEAMGVAREGMVI
NLMPPAIEELGTSSGFSMRLQDRANQGYAALMAAQQQLLAMAAESKLVTGVYPEGLPPGS
SVRLDIDRQKAEALGVSFANISDTLSTAMGSLYVNDFPNAGRMQQVIIQAEARSRMQVED
ILRLHVRNNAGGMVALSEVVTPQWSDAPLQLVRYLGYPAVRIAGSAAPGASSGEAMAEME
RLAAKLPPGFAVEWTGQSLQERQSAAQAPLLMALSMLVVFLVLAALYESWTIPLAVMLVV
PLGLIGAVFAVYARGMPNDVFFKVGMITVIGLSAKNAILIIEFAKQLHEQGMGLIEAAAA
AARLRLRPILMTSLAFALGVVPLMLASGASAETQHAIGTGVFGGMITATVLAVFLVPVYF
VFVLSLSERLAASATLQRLRQRWNKD