Protein Info for Dsui_3003 in Dechlorosoma suillum PS

Annotation: molecular chaperone of HSP90 family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 638 PF02518: HATPase_c" amino acids 30 to 183 (154 residues), 26.7 bits, see alignment E=9.6e-10 PF13589: HATPase_c_3" amino acids 33 to 156 (124 residues), 34 bits, see alignment E=4.4e-12 PF00183: HSP90" amino acids 217 to 630 (414 residues), 447.2 bits, see alignment E=1.5e-137

Best Hits

Swiss-Prot: 82% identical to HTPG_DECAR: Chaperone protein HtpG (htpG) from Dechloromonas aromatica (strain RCB)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 82% identity to app:CAP2UW1_2407)

MetaCyc: 62% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QH05 at UniProt or InterPro

Protein Sequence (638 amino acids)

>Dsui_3003 molecular chaperone of HSP90 family (Dechlorosoma suillum PS)
MGAPKETLGFQAEVKQLLQLMIHSLYSNKEIFLRELVSNASDACDKLRFEALNNNGLYGD
DSELKIRLSFDKAARTLTISDNGIGLSREEAVAHLGTIAKSGTKEFFASLSGDAQKDAHL
IGQFGVGFYSAFIVADKVTVISRRAGLEHNQAVKWESEGAGDYSVEMVEKAGRGTDVILH
LKDGEDDFLNAWKLKSIIRKYSDHITLPIVMKAEKWDEEKKEQVLTDEDETVNQANALWA
RPKSEITEEQYQEFYKHVAHDFENPLGWIHAKVEGKQEYTQLLYIPARAPFDLWDRNARH
GVKLYVKRVFIMDDAEQLMPLYMRFVRGVVDSADLPLNVSREILQQSKDIETIRGGCVKK
VLSLLEGMADSDDAAEKEKYAGFWKEFGNVLKEGVGEDFANKERIAKLLRFASTHHDTTE
QNVSLADYVSRMKEGQEKIYYVTAETFLAAKNSPHLEIFRKKGIEVLLLSDRVDEWVVGH
LTEFDGKPLQSVAKGGLDLGKLEDEAEKKEQEKEAGEYKELTDKVKQALEARVKDVRITH
RLTDSPSCLVSDEHDLSGNLARMLKAAGQKAPEVKPILEINPHHPAVQRLKYEEARFDDW
ANLLFEQAQLAEGGQLEDPAGFVKRINDLMLALSLGGK