Protein Info for Dsui_2890 in Dechlorosoma suillum PS

Annotation: diguanylate cyclase (GGDEF) domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 642 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF00563: EAL" amino acids 57 to 287 (231 residues), 168 bits, see alignment E=3.6e-53 PF00990: GGDEF" amino acids 459 to 545 (87 residues), 49.2 bits, see alignment E=7.6e-17 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 470 to 553 (84 residues), 44.2 bits, see alignment E=8.1e-16

Best Hits

KEGG orthology group: None (inferred from 57% identity to dar:Daro_3571)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QGA8 at UniProt or InterPro

Protein Sequence (642 amino acids)

>Dsui_2890 diguanylate cyclase (GGDEF) domain-containing protein (Dechlorosoma suillum PS)
MALPLFFVLRHRHVTSPAYSGDPASLVEKTMTAASLLERLALNFRAHSLPGAEEADILLE
LIREGRLTPVFQPILDYRGQSYMGFEGLIRGPIDSPLHTPAALFELARRLDLTMELERAC
RIAIFRAFAQLNLPGNLFVNVSPGCLKDPEFRNGETQGLLRELGLSPSRIIIELTENQQI
EDFADLHDALMHYRGQGYRIAIDDLGEGFSNLRLWSELRPEYVKIDRHFIQGIADDALKF
KLVSSMHEIAETCGAYIIAEGIETEADFTTVRDLGIACGQGFFIARPAPTPRTLPESDTL
AALKNRQIAIFPNAGGAGGSTARALSHFIEPIAPDACNDMVYQRFEDNPELHVLPVVHQG
QPLGLINRHNLIDRFARPFRRELYGKKPCTLFMDPAPLVVDQNLSVQEVGLMIARAAKHY
LYDGFVITDQGSYVGVGSGQDLMAMITEMQISAARYANPLTQLPGNVPINEHAERLLESQ
TAFAACYYDIDNFKPFNDAYGYRKGDDVIQMLGLLMAEVADPRLDFIGHIGGDDFIILFQ
SPDWEERCARALRLFDQRMPALVAPEDLARGGFVGEDRKGRTVFNPLPSLSIGALRVEPG
LFSSHHEVAAAASMAKKQAKRQAGSTLFIERRRPGLTAAAAI