Protein Info for Dsui_2701 in Dechlorosoma suillum PS

Annotation: DNA ligase, NAD-dependent

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 796 PF22745: Nlig-Ia" amino acids 7 to 66 (60 residues), 104 bits, see alignment 1.2e-33 TIGR00575: DNA ligase, NAD-dependent" amino acids 14 to 612 (599 residues), 644.6 bits, see alignment E=9.2e-198 PF01653: DNA_ligase_aden" amino acids 72 to 328 (257 residues), 262.2 bits, see alignment E=2.1e-81 PF03120: OB_DNA_ligase" amino acids 332 to 408 (77 residues), 106.9 bits, see alignment E=1.6e-34 PF03119: DNA_ligase_ZBD" amino acids 419 to 445 (27 residues), 41.5 bits, see alignment (E = 3.6e-14) PF12826: HHH_2" amino acids 538 to 600 (63 residues), 61.8 bits, see alignment 2.2e-20 PF00533: BRCT" amino acids 712 to 785 (74 residues), 61.2 bits, see alignment E=3.7e-20 PF12738: PTCB-BRCT" amino acids 729 to 777 (49 residues), 23.9 bits, see alignment 1.4e-08

Best Hits

Predicted SEED Role

"DNA ligase (EC 6.5.1.2)" in subsystem DNA Repair Base Excision (EC 6.5.1.2)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.5.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QPF0 at UniProt or InterPro

Protein Sequence (796 amino acids)

>Dsui_2701 DNA ligase, NAD-dependent (Dechlorosoma suillum PS)
MPVGEVARARAAALRAELESHNHAYYVLDAPTVPDAEYDRLFRELQALEAEYPELLSADS
PTQRVGGKPLDSFPSVSHAVPMLSIQTETDTEPSGAFNFDARVRKELELEEGAAPVEYAA
ELKFDGLAVSLRYEHGVLVQGATRGDGASGEDVTQNLRTVRSIPLRLQGPAASLPPLLEV
RGEVYMRRDDLARYNEKALARGDKTLVNPRNGAAGSIRQLDPAIAASRPLNFFAYGIGAV
SGWTLPATHAGLLDALAAFGLPVCQHRDVVRGAAGLADFHRRMGALRDSLPFDIDGVVYK
VNSLELQARLGFRSREPRWAVAHKYPAQEALTVVEAIDIQVGRTGALTPVARLQPVFVGG
VTVTNATLHNEDEMARKGGLCTGDTVIVRRAGDVIPEVVGVVAERRPAGATPFQMPRSCP
VCGSHVVKEEGEAVARCSGGFACRAQRIQAILHFAGRRMMDIEGLGERYVERLVEFDLIH
GVADLYRLTLADLLEMKRLADERDGVTPETVKQGQIATRWAENLLAGIAASKTPPLARLL
FALGIRHVGESTAKTLADWLGSLAVVRRAPAPLLAALPDIGATVATAIADFFAEPHNAAA
VDALLAAGVAPADEHAPSPELGGRLGWTELYAALGIPRLTPVRARQLADLVPEGEGLAAL
APGCLELAALPAEVATAVLAWLEEEGNRARLTALAALRRELLAALPAQALGPRPLAGLTF
VLTGTLPTLKRDEAKARIEAQGGKVSGSVSKKTDYVVAGEEAGSKLENALKLGVPVLDET
ALLNLLNEEKSNEKSA