Protein Info for Dsui_2497 in Dechlorosoma suillum PS

Annotation: mercuric reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 548 PF00403: HMA" amino acids 4 to 63 (60 residues), 55.3 bits, see alignment 1.7e-18 PF07992: Pyr_redox_2" amino acids 87 to 405 (319 residues), 231.6 bits, see alignment E=3.4e-72 TIGR02053: mercury(II) reductase" amino acids 87 to 548 (462 residues), 623.8 bits, see alignment E=1e-191 PF13738: Pyr_redox_3" amino acids 217 to 389 (173 residues), 41.7 bits, see alignment E=2.3e-14 PF00070: Pyr_redox" amino acids 259 to 327 (69 residues), 51.6 bits, see alignment E=2.9e-17 PF02852: Pyr_redox_dim" amino acids 424 to 532 (109 residues), 104.6 bits, see alignment E=8.6e-34

Best Hits

Swiss-Prot: 100% identical to MERA_PSEFL: Mercuric reductase (merA) from Pseudomonas fluorescens

KEGG orthology group: K00520, mercuric reductase [EC: 1.16.1.1] (inferred from 100% identity to enc:ECL_03824)

Predicted SEED Role

"Mercuric ion reductase (EC 1.16.1.1)" in subsystem Mercuric reductase or Mercury resistance operon (EC 1.16.1.1)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.16.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QML8 at UniProt or InterPro

Protein Sequence (548 amino acids)

>Dsui_2497 mercuric reductase (Dechlorosoma suillum PS)
MTEITVNGMTCTSCATHVKDALEKIPGVNAAVVSYPESRAQVMADTAVSHNQLLAAIAAL
GYQGSIRVGDFKDEPKIRDALEGAGLHIAIIGSGGAAMAAALKAVEQGATVTLIERGTIG
GTCVNIGCVPSKIMIRAAHIAHLRRESPFDGGIAATVPAIDRSKLLAQQQARVDELRHAK
YEGILDGNPAITVLHGEARFKDDQSLVVRLNEGGEREVTFDRCLVATGASPAVPPIPGLK
ESPYWTSTEALVSDTIPARLAVIGSSVVALELAQAFARLGSQVTILARSTLFFREDPAIG
EAVTAAFRAEGIEVLEHTQASQVAHVNGEFVLTTGHGELRADKLLVATGRAPNTRSLALD
AAGVTVNAQGAIVIDQGMRTSNPNIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALN
LTAMPAVVFTDPQVATVGYSEAEAHHDGIETDSRTLTLDNVPRALANFDTRGFIKLVIEE
GSGRLIGVQAVAPEAGELIQTAVLAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFNKDV
KQLSCCAG