Protein Info for Dsui_2217 in Dechlorosoma suillum PS

Annotation: 2-oxoglutarate dehydrogenase, E1 component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 940 PF16078: 2-oxogl_dehyd_N" amino acids 8 to 47 (40 residues), 62.6 bits, see alignment (E = 4e-21) TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 11 to 935 (925 residues), 1213.3 bits, see alignment E=0 PF00676: E1_dh" amino acids 207 to 513 (307 residues), 152.4 bits, see alignment E=2.9e-48 PF02779: Transket_pyr" amino acids 593 to 789 (197 residues), 171.8 bits, see alignment E=2.3e-54 PF16870: OxoGdeHyase_C" amino acids 795 to 936 (142 residues), 164.2 bits, see alignment E=3.8e-52

Best Hits

Swiss-Prot: 64% identical to ODO1_CUPNH: 2-oxoglutarate dehydrogenase E1 component (odhA) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 72% identity to azo:azo1555)

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QK97 at UniProt or InterPro

Protein Sequence (940 amino acids)

>Dsui_2217 2-oxoglutarate dehydrogenase, E1 component (Dechlorosoma suillum PS)
MMMQNFGTSYLFGGNAPFVEELYENYLDNPASVPDEWREYFDKLAQQPGAAARDVPHFPV
IAAFAEQGKRGPVRTVVAAGDDKKQVAVLQLINAYRFLGNRWANLDPLKRQERPEIQELE
PSFYGFTPADLNEPFNTGSFQFGADRAPLGQIIEALKETYCGSIGVEYMYMSDIAQKRWL
QERLEPSRGNGNYTPERKKRLLDRLTVAETLERYLHTRYVGQKRFSLEGGESLIVAMDEV
IRTGAATGVQEIVIGMAHRGRLNVLVNTLGKAPKMLFDEFEGKKAQDLSSGDVKYHMGFS
SDVSTDHGPVHLTLAFNPSHLEIVNPVVEGSVYARQRRRGGDDAAKAQILPVLIHGDAAV
AGQGVNQEMLNFSQTRGYGTGGTVHVVVNNQIGFTTSDPRDYRSSLYCSDIFKMVEAPIF
HVNGDDPEAVALVTQLALEFRQTFKKDVVIDIICFRKLGHNEQDEPMVTQPLMYKKIQAH
PGTRKLYADKLVAQGVLSADGPDQIIKDFRAALDQGKLLSDPVLSNYKRQHANDWAPYTN
KKYTELGNTKVPKKELQRLAKRLTAIPENFTMHSRVKKIIEDRAQMGEGKLPVDWGMAEN
LAYATLLAQGYGVRISGEDVGRGTFFHRHGVLHDQNREKWDAGSYIPLANLQEDQGNFQS
FDSVLSEEAVLAFEYGYATAEPNELVVWEGQFGDFANGAQVVIDQFLCSGEAKWGRACGL
TLLLPHGYEGQGPEHSSARLERYMQLSAEFNWEVCYPSNAAQIFHLLRRQMVRKQRKPLV
VMTPKSLLRNPSASCSLDELANGTFQTIIGETEKLEAKKVTRVIACAGKVYYDLVAARKE
RKLENIAILRVEQLYPFDDKRFDEELSKFPNAKELVWCQEEPLNQGAWYAKAHRLQVALK
KGQTLHVVARPAAAAPAVGYLAKHVEQQKALLEEALGKLN