Protein Info for Dsui_2189 in Dechlorosoma suillum PS

Annotation: acyl-CoA synthetase (NDP forming)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 896 PF02629: CoA_binding" amino acids 13 to 105 (93 residues), 47.7 bits, see alignment E=1e-15 PF13380: CoA_binding_2" amino acids 15 to 140 (126 residues), 87.9 bits, see alignment E=3.1e-28 PF13607: Succ_CoA_lig" amino acids 157 to 292 (136 residues), 174.3 bits, see alignment E=5.2e-55 PF19045: Ligase_CoA_2" amino acids 306 to 438 (133 residues), 40.1 bits, see alignment E=1.8e-13 PF13549: ATP-grasp_5" amino acids 484 to 705 (222 residues), 281.3 bits, see alignment E=2.1e-87 PF13302: Acetyltransf_3" amino acids 740 to 877 (138 residues), 39.9 bits, see alignment E=3.2e-13 PF00583: Acetyltransf_1" amino acids 782 to 876 (95 residues), 38.2 bits, see alignment E=6.9e-13 PF13508: Acetyltransf_7" amino acids 795 to 877 (83 residues), 30.8 bits, see alignment E=1.4e-10

Best Hits

KEGG orthology group: K09181, hypothetical protein (inferred from 75% identity to app:CAP2UW1_3266)

Predicted SEED Role

"Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QJT1 at UniProt or InterPro

Protein Sequence (896 amino acids)

>Dsui_2189 acyl-CoA synthetase (NDP forming) (Dechlorosoma suillum PS)
MHEEEHYLTSLFEPKSVAVIGASDRENSVGNIIYRNIVAAGYKGRLYPINPKHDTVQGVQ
AYKSIEEIGARVDLAVIATQARTVPAIIEQCGRSGVKNVVVITAGFAEAGHSGAALERKM
VEIARSYGVRILGPNCLGLIRPVQGLNATFANISANPGNLALVSQSGALCTAILDWAKVN
DVGFSSVISTGGSADIDFGEILDYLVYDNRTHYILMYVEGIRNARRFMSAMRSAARIKPI
LLLKAGRYESGSVAAQVHSGMALGSDAVFDAALKRAGVVRVRNIGQLFYAAKGLASKFRP
DGNKLLIITNGGGPGAMAADRAAELGIPLADLSQSTIASLNAVLPPTWSHANPIDIVGDA
TPERYRDAILAGTQDPEVDGILVMLTPQAMTQPEEVAKAVITASETCTKPIVGCWMGEQQ
TYPARKMLTEAGIPAFRMPETAVDLFSHLSTYYRNQKLLLQTPEPISRQAKTATEGAKML
IEAVLSERRKVLSEMESKSVLRAFKIPVAQTMVARTPTEALLLAEQIGFPVVMKVDSPDL
PRKSEVGGVRLNIISAAAVRNAYHDILDTVGRNAPSARINGVSIEPFVARPNGRELKVGV
IRDRVFGPVITFGVGGAECEVFNDTAVALPPMNSYLVEDLIRSTRAAKILGDYRNMPAAN
MEALEDVLLRISQMVCELPWLQELDLNPLIVDENGAIAADARIVIDFAPSSGDRYSHMAI
HPYPAHLVEDWVLPDGQVVVIRPIRPEDAEMEKEFVAHLSDESKYFRFMDTLRELTQSML
VRFTQIDYDREMAFVAVTEEDGKEVQVGVSRFVSNPDGETVEFALAVADGWQKRGVGRKL
MSAIIECARAKGYRAVVGDVLALNSKMFKLMTSLGFTIHPHPEDPAVKRVIKPLTD