Protein Info for Dsui_1148 in Dechlorosoma suillum PS

Annotation: putative transcriptional regulator with CopG/Arc/MetJ DNA-binding domain and metal-binding domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 162 PF01402: RHH_1" amino acids 3 to 41 (39 residues), 41.6 bits, see alignment E=8.2e-15 PF08753: NikR_C" amino acids 54 to 129 (76 residues), 110 bits, see alignment E=5.2e-36

Best Hits

Swiss-Prot: 53% identical to NIKR_EDWI9: Nickel-responsive regulator (nikR) from Edwardsiella ictaluri (strain 93-146)

KEGG orthology group: K07722, CopG family transcriptional regulator, nickel-responsive regulator (inferred from 69% identity to azo:azo3128)

Predicted SEED Role

"Nickel responsive regulator NikR" in subsystem Transport of Nickel and Cobalt

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QKU5 at UniProt or InterPro

Protein Sequence (162 amino acids)

>Dsui_1148 putative transcriptional regulator with CopG/Arc/MetJ DNA-binding domain and metal-binding domain (Dechlorosoma suillum PS)
MERITISLDEDLAREFDALIAARGYSNRSEAVRDILRSQLETWRQARKESDHCVANLSYV
YNHHERELAERLTSIQHDHHDLTVSTLHAHLDHEHCIESTILKGPTEDVRAFAQALMAER
GVRHGQLNLVTVELDESQKQHSHKHSHAHGHGYRHLHLKPSR