Protein Info for Dsui_1105 in Dechlorosoma suillum PS

Annotation: methylmalonyl-CoA mutase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02310: B12-binding
  • amino acids 20 to 117 (98 residues), 47.8 bits, E=2.4e-16
• PF03308: MeaB
  • amino acids 177 to 408 (232 residues), 140.7 bits, E=9.8e-45
• PF02492: cobW
  • amino acids 207 to 375 (169 residues), 30.7 bits, E=4.5e-11
• PF01642: MM_CoA_mutase
  • amino acids 570 to 1086 (517 residues), 414.8 bits, E=1e-127
• TIGR00641: methylmalonyl-CoA mutase N-terminal domain
  • amino acids 727 to 1091 (365 residues), 305.8 bits, E=4.5e-95

Best Hits

KEGG orthology group: K11942, methylmalonyl-CoA mutase [EC: 5.4.99.2] (inferred from 86% identity to eba:ebA3766)

Predicted SEED Role

"B12 binding domain / kinase domain / Methylmalonyl-CoA mutase (EC 5.4.99.2)" in subsystem Propionyl-CoA to Succinyl-CoA Module or Serine-glyoxylate cycle (EC 5.4.99.2)

MetaCyc Pathways

• superpathway of anaerobic energy metabolism (invertebrates) (14/17 steps found)
• propanoyl CoA degradation I (3/3 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• conversion of succinate to propanoate (2/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
• pyruvate fermentation to propanoate I (4/7 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (7/13 steps found)
• 3-hydroxypropanoate cycle (7/13 steps found)
• superpathway of L-methionine salvage and degradation (9/16 steps found)
• methylaspartate cycle (11/19 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (10/18 steps found)
• L-glutamate degradation VIII (to propanoate) (4/11 steps found)
• superpathway of the 3-hydroxypropanoate cycle (7/18 steps found)
• crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) (3/14 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 5.4.99.2

Use Curated BLAST to search for 5.4.99.2

Sequence Analysis Tools

See G8QK74 at UniProt or InterPro

Protein Sequence (1093 amino acids)

>Dsui_1105 methylmalonyl-CoA mutase family protein (Dechlorosoma suillum PS)
MTDLSIAKKIVPYKPKNKVRFITAASLFDGHDASINIMRRILQSTGSEVIHLGHNRSVGD
IVNAALQEDVQGIAITSYQGGHVEFFKYMIDLLKENGGENIKVFGGGGGVIVPSEIKELH
EYGVTRIYSPEDGQHLGLQGMINDVVEQSDYNLTTLAPQKPEEVMAALQSGNRRALARIV
SALENGAYPEGLRKQIVEAAALVATTPTLGITGTGGAGKSSLTDELVRRFRLDQEDGLKL
AIISIDPSRKRTGGALLGDRIRMNAIEHPNIFMRSLATRETGSEISAALPEVIAACKLSG
FDLIIVETSGIGQGDAAIVPLVDASLYVMTPEFGAASQLEKIDMLDFADFVAINKFDRKG
AEDALRDVRKQYQRNRELFTQSPDEMPVFGTMAARFNDDGVTALYQAILPKLVEFGLKAK
AGKLPVVTVKESSRGRAIVPVERTRYLAEIADTLRAYHKHTEEQVKIARERQSLRISKDL
FNSYDEAAKAALPKFDELIACKESELDAKAKKLLDMWPDTVKAYSGDEYVVKIRDKEIRT
KLVSESLSGTKIKKVVLPRFTDDGETLRFLMKENVPGSFPYTAGVFAFKREGEDPTRMFA
GEGDAFRTNRRFKKVSEGMPAHRLSTAFDSVTLYGCDPDVRPDIYGKIGNSGVSIATLDD
MKVLYSGFDLVCPTTSVSMTINGPAPIILACFFNTAIDQQLDKFRADNGREPTEDEAEKI
REWVLASVRGTVQADILKEDQGQNTCIFSTEFALKMMGDIQEFFVHNQVQNFYSVSISGY
HIAEAGANPISQLAFTLANGFTYVESYLARGMHIDDFAPNLSFFFSNGMDPEYSVIGRVA
RRIWAVAMKNKYGANERSQKLKYHIQTSGRSLHAQEMDFNDIRTTLQALIAIYDNCNSLH
TNAYDEAITTPTEESVRRAMAIQLIINREWGVAKNENPNQGAFIIDELTDLVEEAVLKEF
EAIASRGGVLGAMETGYQRGKIQEESLYYEHKKHDGSYPIIGVNTFLNPKGSAQVEIELA
RSTEEEKQSQIARLKDFHQRNADKAPAMLAKLKQTVIENGNVFAVLVEAVRVCSLGQITG
ALYEVGGQYRRSM