Protein Info for Dsui_1076 in Dechlorosoma suillum PS

Annotation: copper/silver-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 760 transmembrane" amino acids 106 to 124 (19 residues), see Phobius details amino acids 136 to 157 (22 residues), see Phobius details amino acids 168 to 192 (25 residues), see Phobius details amino acids 203 to 222 (20 residues), see Phobius details amino acids 357 to 380 (24 residues), see Phobius details amino acids 386 to 408 (23 residues), see Phobius details amino acids 702 to 721 (20 residues), see Phobius details amino acids 727 to 749 (23 residues), see Phobius details PF04945: YHS" amino acids 4 to 48 (45 residues), 51.1 bits, see alignment 2.7e-17 PF19335: HMBD" amino acids 60 to 85 (26 residues), 43 bits, see alignment (E = 8.7e-15) TIGR01511: copper-translocating P-type ATPase" amino acids 149 to 752 (604 residues), 579.3 bits, see alignment E=1.9e-177 TIGR01525: heavy metal translocating P-type ATPase" amino acids 168 to 751 (584 residues), 601.1 bits, see alignment E=5e-184 TIGR01494: HAD ATPase, P-type, family IC" amino acids 212 to 720 (509 residues), 289.6 bits, see alignment E=7.3e-90 PF00122: E1-E2_ATPase" amino acids 241 to 341 (101 residues), 103.4 bits, see alignment E=1.3e-33 PF00702: Hydrolase" amino acids 439 to 656 (218 residues), 115.4 bits, see alignment E=1.1e-36 PF08282: Hydrolase_3" amino acids 627 to 686 (60 residues), 22.4 bits, see alignment 2.4e-08

Best Hits

Swiss-Prot: 56% identical to SILP_SALTM: Silver exporting P-type ATPase (silP) from Salmonella typhimurium

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 81% identity to dar:Daro_2267)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QK45 at UniProt or InterPro

Protein Sequence (760 amino acids)

>Dsui_1076 copper/silver-translocating P-type ATPase (Dechlorosoma suillum PS)
MSDIDPVCGMTVKPDSPHASDFGGTHYRFCSGKCKAKFDADPRQYLHPRQEEKAPTGAEY
TCPMHPEVRQLGPGTCPKCGMALEPIIPELEAEEGNSEYRDFRFRFWGSLPLTLLVVMLA
MAGHQLEFLAPQLRTWAEMVLSVPIVFWAGAPFFIRCWQSLVHRTPNMWTLIGIGTGAAF
SYSVVAALAPGLFPASFEAHGRIGVYFEAAAVIISLTLLGQMLELRARSQTSAAIKSLLG
LAPKTARRINADGTEEDIPLNYVHVGDTLRVRPGEKVPVDGEVTEGSSAVDESMLTGEPI
PVTKRPGDKVIGATMNTSGSLIIRSEKIGSETMLAQIVQMVAQAQRSKAPMQRMADVVAG
YFVIVVVAIALLSFFGWGFFGGEKGWLFGLINGVSVLIIACPCALGLATPMSIMVATGKA
ATQGVLFRDAAAIERLREIDTLIVDKTGTLTEGKPTFECAIGAPGVDQQEVLRLAASLDQ
GSEHPLAVAIVQAARDQSLNLEKVEGFESASGIGVRGMLAGKQLALGNTVLMSQDGVEVA
PMAGQAETLRQGGASVMYLAVNGRLQGVLAVSDPVKASTPEALAVLRAAGLRVVMATGDG
ETTARAVGQRLGISEVHGEVKPADKLALVERLQREGRVVAMAGDGINDAPALAKADVGIA
MGTGTDVAMNSAQVTLVKGDLRGIARARLLSAATVGNMRQNLAFAFLYNALGVPVAAGIL
YPAFGLVLSPIIAAAAMSLSSLSVVSNALRLRGIKAANLT