Protein Info for Dsui_1065 in Dechlorosoma suillum PS

Annotation: copper/silver-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 739 transmembrane" amino acids 93 to 112 (20 residues), see Phobius details amino acids 124 to 142 (19 residues), see Phobius details amino acids 154 to 176 (23 residues), see Phobius details amino acids 185 to 204 (20 residues), see Phobius details amino acids 338 to 360 (23 residues), see Phobius details amino acids 367 to 386 (20 residues), see Phobius details amino acids 683 to 701 (19 residues), see Phobius details amino acids 707 to 726 (20 residues), see Phobius details PF00403: HMA" amino acids 14 to 73 (60 residues), 58.1 bits, see alignment 1.4e-19 TIGR01511: copper-translocating P-type ATPase" amino acids 138 to 727 (590 residues), 574.8 bits, see alignment E=4.4e-176 TIGR01525: heavy metal translocating P-type ATPase" amino acids 156 to 726 (571 residues), 610.8 bits, see alignment E=6e-187 TIGR01494: HAD ATPase, P-type, family IC" amino acids 194 to 707 (514 residues), 285.8 bits, see alignment E=9.7e-89 PF00122: E1-E2_ATPase" amino acids 222 to 322 (101 residues), 101.5 bits, see alignment E=3e-33 PF00702: Hydrolase" amino acids 418 to 638 (221 residues), 104 bits, see alignment E=2.1e-33

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 68% identity to mpt:Mpe_A1640)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QK34 at UniProt or InterPro

Protein Sequence (739 amino acids)

>Dsui_1065 copper/silver-translocating P-type ATPase (Dechlorosoma suillum PS)
MSAFTSTIRTTNHTLLVDGMSCASCVARVEKALLKVPGVQEASINLASEKATVITLPDVS
FATLAAAIGKAGYAASPETAGEVPAVKRRFPEWWPVAVSIVLTLPLLAPMLLELLGKEWM
LDGWWQLALATPVQFWLGLRFYRAGWKAVRARAGNMDLLVALGTSAAYGLSVYLLWRNAD
TRMPHLYFEASAAVITLVLLGKWLEARAKRQTTDAIRSLNALRPTVARVLIEGQEVSIPV
QQVAIGDKVVVRPGERIPVDGTVINGQSHVDEALITGESLPIAKAPGDQVTGGSVNGEGL
MVLRTIAIGTETTLARIIRMVESAQAAKAPIQRIVDRISAVFVPVVLSIAILTFIVWVLL
LADWEVALINAVTVLVIACPCALGLATPTSIMAGTGVAARHGILIKDAEALEIAHSVTAV
AFDKTGTLTEGKPMLVAVEAVEGMDKNNILQLSAALQKTSDHPLAHAVLEMAKSQQLAVP
DTVNAKALPGRGVQGVVGGEILMLGSTRLMLESGTAPARLLERAAALEKQGRTISWLLRS
RGNETETLGLLAFGDAVKGASYQAVANLHKLGIKTVMLTGDNQGSANAVAENLGIDEVWA
GLLPEDKASIIQDLRDRGYVVAMVGDGLNDAPSLVAADVGLSMSTGTDVAMQAAGITLMR
GDPRLVADSLDVSRRTYGKIKQGLFWAFAYNILGIPLAAAGMLSPVVAGAAMAFSSVSVV
MNALLLRRWRSASDIRHPD