Protein Info for Dsui_0803 in Dechlorosoma suillum PS

Annotation: PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 transmembrane" amino acids 22 to 43 (22 residues), see Phobius details amino acids 297 to 316 (20 residues), see Phobius details PF22588: dCache_1_like" amino acids 190 to 277 (88 residues), 28.5 bits, see alignment E=5.1e-10 PF13188: PAS_8" amino acids 330 to 385 (56 residues), 23.5 bits, see alignment 1.4e-08 amino acids 457 to 492 (36 residues), 21.5 bits, see alignment (E = 6e-08) TIGR00229: PAS domain S-box protein" amino acids 331 to 451 (121 residues), 32.2 bits, see alignment E=1e-11 amino acids 456 to 572 (117 residues), 61.7 bits, see alignment E=7.5e-21 PF08448: PAS_4" amino acids 333 to 446 (114 residues), 47.5 bits, see alignment E=6.5e-16 amino acids 460 to 567 (108 residues), 36.9 bits, see alignment E=1.3e-12 PF00989: PAS" amino acids 354 to 440 (87 residues), 26.1 bits, see alignment E=2.5e-09 amino acids 455 to 563 (109 residues), 51.2 bits, see alignment E=4.1e-17 PF13426: PAS_9" amino acids 355 to 443 (89 residues), 29.8 bits, see alignment E=2.2e-10 amino acids 463 to 565 (103 residues), 60.6 bits, see alignment E=5.7e-20 PF08447: PAS_3" amino acids 476 to 557 (82 residues), 28.9 bits, see alignment E=4.1e-10 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 573 to 738 (166 residues), 136.2 bits, see alignment E=9.2e-44 PF00990: GGDEF" amino acids 577 to 737 (161 residues), 165.8 bits, see alignment E=2.5e-52

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QHQ9 at UniProt or InterPro

Protein Sequence (750 amino acids)

>Dsui_0803 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein (Dechlorosoma suillum PS)
MKTDAPIRPQVSLRPIRRGVEALPLLLALLLSALLWAAVDIILAHEKERELEHGYRQLDY
LRRTFQEHSHNTLTTADQILRLLKAEFEERPGTREFSEFRRALEHSSIFVQLGVIGADGE
LQWSNVPFKQVNLKDREHFQVHVDRDSGQVFISKPVLGRASGKWSIQLSRRLNHQDGSFA
GVAVASVDPQYLARFYQEVGLQAGTVLGLIGYDRVLRVRVTDKETAIGQTLSDGAPLLRA
LHQGSDGRFRAPSSFDGTMRLYSYGQMPGLALSVVAGFDEAQVLAPYQERARSYRRITAA
STAALLLTGLLLWWLLARLRQARQEVEAAHAVFSASPDPMVMLQRDPGGHFHYRYFNPAA
LTLAGRRAEEMQHHPLDQVLTPEDALRRQLMLEQTVRSGQVQEAEQTTTYPSGERTVRWT
AVPVHDGSDHISHVALIGHDLTQLREEQRQLWLSDAIVAQTHEAVMVTDASERIFRVNPA
FCLMTGYAPEEVEDHSPGLLASGVHDAEFYHHMHQALQSRGFWQGEVWQRHKDGHLFACL
LDISTLRDGEGRLTHYVHVFSDITEQKHLAEQMEHLAHFDGLTQLPNRNLFQDRLCQALA
RAERNGTGLALMFMDLDGFKAVNDSAGHNTGDRLLVEVARRITSVLRKVDSVSRQGGDEF
TVLLESLNNGQGIAETEEAARRIIAAINEPVLLDGRSFRVGASIGIAFYPADGDNVELLM
ARADAAMYQAKARGKNRHLCWTPELAPGEA