Protein Info for Dsui_0541 in Dechlorosoma suillum PS

Annotation: cobalamin biosynthesis protein CobD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 323 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 55 to 77 (23 residues), see Phobius details amino acids 81 to 99 (19 residues), see Phobius details amino acids 156 to 178 (23 residues), see Phobius details amino acids 245 to 264 (20 residues), see Phobius details amino acids 296 to 317 (22 residues), see Phobius details PF03186: CobD_Cbib" amino acids 12 to 291 (280 residues), 304.3 bits, see alignment E=4.1e-95 TIGR00380: cobalamin biosynthesis protein CobD" amino acids 13 to 272 (260 residues), 185.7 bits, see alignment E=6e-59

Best Hits

KEGG orthology group: K02227, adenosylcobinamide-phosphate synthase CobD [EC: 6.3.1.10] (inferred from 64% identity to eba:ebA2136)

Predicted SEED Role

"Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)" (EC 6.3.1.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.1.10

Use Curated BLAST to search for 6.3.1.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QFE4 at UniProt or InterPro

Protein Sequence (323 amino acids)

>Dsui_0541 cobalamin biosynthesis protein CobD (Dechlorosoma suillum PS)
MPSWLALPLAALLGVGLDRLLGEPRRGHPLVAFGALANLLEKALRPPPAVASRSALRIFG
LLAWSFAVLPPVLLAAWASATPWLGILADAGLLYFALGARSLKEHADAVAVPLAGGDLAT
ARQKVGYMVSRDTTALDESGVAKACVESVLENGNDAVFGTLFWFALLGGPGALLFRLANT
LDAMWGYKNERFLHFGWAAARLDDLLNWPAARLTALTYAWLGNTRRALACWKAQAPTWES
PNAGPVMAAGAGSLGVLLGGAAIYHGREEQRPPLGEGRPAAAFDIDRASHLVQRGLVLWL
AAIVALLPLIALVQFLLGKVFHA