Protein Info for Dsui_0540 in Dechlorosoma suillum PS
Annotation: L-threonine-O-3-phosphate decarboxylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K02225, cobalamin biosynthetic protein CobC (inferred from 52% identity to pmk:MDS_3108)Predicted SEED Role
"L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 4.1.1.81)
MetaCyc Pathways
- adenosylcobalamin biosynthesis II (aerobic) (27/33 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (29/36 steps found)
- aminopropanol phosphate biosynthesis I (1/2 steps found)
- superpathway of L-threonine metabolism (11/18 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.1.81
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See G8QFE3 at UniProt or InterPro
Protein Sequence (334 amino acids)
>Dsui_0540 L-threonine-O-3-phosphate decarboxylase (Dechlorosoma suillum PS) MLEHGGRLRQAARQWGIPLADWLDLSTGINPWAYPIPGIPINAWQRLPEEEDGLEAAARN YYGAKHVLALAGSQAAIQTLPKLLPPGRAAVLAPSYAEHAAAWVKAEWAVTPFAPPRLEE VAKEHNVVVVVNPNNPTGERITARRLRAAARALAKRGGLLVVDEAFADADPRDSLADLAG TKAAPNIIVLRSLGKFFGLAGARVGFAIGRPELLEALADTLGPWPVAGPARWVARCALED RAWQADMRQELQVAAERLETLLQDSLGASTGTGLFRWLPHPRADWVYDELARRGILVRLF LEVDGSSSLRFGLPGSDDEWRRLEGALNELRKDL