Protein Info for Dsui_0459 in Dechlorosoma suillum PS

Annotation: DNA polymerase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 910 PF02739: 5_3_exonuc_N" amino acids 4 to 168 (165 residues), 185.3 bits, see alignment E=1.5e-58 TIGR00593: DNA polymerase I" amino acids 4 to 910 (907 residues), 910.2 bits, see alignment E=8.6e-278 PF01367: 5_3_exonuc" amino acids 169 to 263 (95 residues), 92.6 bits, see alignment E=3.8e-30 PF01612: DNA_pol_A_exo1" amino acids 313 to 495 (183 residues), 105.5 bits, see alignment E=5.5e-34 PF00476: DNA_pol_A" amino acids 534 to 908 (375 residues), 538.4 bits, see alignment E=1.9e-165

Best Hits

KEGG orthology group: K02335, DNA polymerase I [EC: 2.7.7.7] (inferred from 74% identity to app:CAP2UW1_1117)

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QPL7 at UniProt or InterPro

Protein Sequence (910 amino acids)

>Dsui_0459 DNA polymerase I (Dechlorosoma suillum PS)
MPMLLLVDGSSYLYRAFHALPDLRNKAGEPTGAIYGVLNMLRRLESDYKAEGVTYKAVVF
DAKGKTFRDDWYPEYKAQRPPMPTDLVAQIEPLHAAIKASGWPLLMEDGVEADDVIGTLA
RQAEAAGMDVVISTGDKDLTQLVSPRVRWVNTMSNEVLDEAGVTAKFGVEPGRIVDYLAL
IGDTVDNVPGVAKVGPKTALKWLEQYGTLDNIMANAEAIGGVVGNNLRQALDFLPLGKKL
VTVVCDLPLPETPASLAPRPLDKAALEEIFSRYEFKTWLRELQGEGAAAGDAEAAGDATT
APAAPAGAHRQHYETILTWEAFERWLAKIQAAPLVALDTETTSLDPLSARIVGISFALTP
GEAAYIPVAHNYPGAPDQLPREQVLARLKPWLEASNHAKLGQNLKYDQHVFANHDIALKG
IVHDTLLQSYVLESDKGHDLEQLARRHLGLETIPYTALCGKGANQIGFDQVAIDQAAEYS
AEDSDLTLRVHQNLFPAIAADAKLNCIYSDIEMPAREVLFAMERHGVLIDSGLLQAQSNE
LGRKLVELEAKAVEIAGQPFNLNSPKQLAEILFTQLGLPVVKKTPGGAPSTDEEVLSELA
LDYPLPKALLEYRGLAKLKSTYTDKLPRMVNPHTGRVHTSFSQAVAVTGRLASSDPNLQN
IPVRTAEGRRIRAAFIAPPGCKIVSADYSQIELRIMAHLSGDHGLLDAFAKGEDVHRATA
AEIFGIMPLEVTAEQRRYAKTINFGLIYGMSAFGLARSLEIERSAAQTYIERYFARYPGV
ARYMEETRELAKRQGYVETVFGRRLWLPDIRASQAGRRQGAERAAINAPMQGTAADIVKL
AMTATARWLADSGLQSSLVLQVHDELVLEVPEGELARVRAELPAIMGQVAKLAVPLVVDV
GVGNNWDEAH