Protein Info for Dsui_0437 in Dechlorosoma suillum PS

Annotation: succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 19 to 478 (460 residues), 587 bits, E=1.2e-180
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 28 to 477 (450 residues), 742.8 bits, E=7.2e-228

Best Hits

Swiss-Prot: 70% identical to GABD_ECOLI: Succinate-semialdehyde dehydrogenase [NADP(+)] GabD (gabD) from Escherichia coli (strain K12)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 73% identity to mca:MCA1756)

MetaCyc: 70% identical to succinate-semialdehyde dehydrogenase (NADP+) GabD (Escherichia coli K-12 substr. MG1655)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]; Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.79, 1.2.1.20]

Predicted SEED Role

No annotation

MetaCyc Pathways

• TCA cycle IV (2-oxoglutarate decarboxylase) (8/9 steps found)
• 4-aminobutanoate degradation II (1/2 steps found)
• 4-aminobutanoate degradation III (1/2 steps found)
• superpathway of 4-aminobutanoate degradation (1/3 steps found)
• L-lysine degradation X (3/6 steps found)
• L-lysine degradation I (3/7 steps found)
• L-lysine degradation IV (1/5 steps found)
• L-lysine degradation III (1/6 steps found)
• 4-hydroxyphenylacetate degradation (2/8 steps found)
• superpathway of L-arginine and L-ornithine degradation (5/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (3/11 steps found)
• nicotine degradation II (pyrrolidine pathway) (2/11 steps found)
• nicotine degradation I (pyridine pathway) (4/17 steps found)
• superpathway of L-lysine degradation (9/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.79

Sequence Analysis Tools

See G8QPJ5 at UniProt or InterPro

Protein Sequence (483 amino acids)

>Dsui_0437 succinate-semialdehyde dehydrogenase (Dechlorosoma suillum PS)
MKLEDSNLLRQQCYLNGQWVGGESDFPVHNPASGAELARVPRFGAAETRAAIAAADAAWP
AWRSRTAKERTGVLRRWFELMNQHADDLALLMTSEQGKPLAEARGEVAYAASFVEWFAEE
AKRAYGETIPAVAADKRMLVIKQPIGVCAAITPWNFPAAMITRKVAPALAAGCTVVVKPA
EQTPLTALALAELAHRAGFPAGVFNVITGDPVAIGGELTSNPTVRKLSFTGSTEVGRLLM
GQCAPSIKKLSLELGGNAPFIVFDDADLDAAVEGAMISKYRNTGQTCVCANRLLVQDGIY
EAFAARLAAKVATLKVGEGTEAGVTQGPLIDADALAKVEAHIADAVAHGARVLAGGRRHE
RYREGGAFFQPTVLADVTPQMRVAREETFGPVAPLFRFQTEEEAIALANATEFGLASYFY
SRDIGRIFRVGEALEYGMVGVNTGLISNEVAPFGGIKQSGLGREGSKYGLEEYLEVKYLC
LGL