Protein Info for CSW01_19480 in Vibrio cholerae E7946 ATCC 55056

Annotation: HlyD family type I secretion periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 481 transmembrane" amino acids 52 to 70 (19 residues), see Phobius details TIGR01843: type I secretion membrane fusion protein, HlyD family" amino acids 49 to 481 (433 residues), 453.7 bits, see alignment E=3.3e-140 PF13533: Biotin_lipoyl_2" amino acids 89 to 125 (37 residues), 24.9 bits, see alignment 2e-09 PF13437: HlyD_3" amino acids 334 to 449 (116 residues), 60.1 bits, see alignment E=5e-20

Best Hits

KEGG orthology group: K02022, (no description) (inferred from 100% identity to vco:VC0395_0162)

Predicted SEED Role

"Type I secretion system, membrane fusion protein LapC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (481 amino acids)

>CSW01_19480 HlyD family type I secretion periplasmic adaptor subunit (Vibrio cholerae E7946 ATCC 55056)
MAHVIKSTDYQWCEQEPLMSNRSYNKLTAEELDYVDDKTAALLLNTPHSARIILWVMVAF
FILAIAWASWAEIDKVTVGQGKVVPSSQVQVIQNLEGGLVKQILVREGEQVQKGQQLILL
DDTRFRSDFREREQQVANLTASVLQLSASISSVIIDENFEEKNWANSVQLDYSKLAFPPV
LSDSQPDLVERQRDQYRQDLDNLRNQLSVLSQQIKQKQQDLIEAEARIINLRQSYDYAKK
ELDITEPLANEGVVPKIELLKLQRQLNDTRRELTSTELKIPVLKSAVREAMLSRINAAQK
FRTEQQDKLNQAQDKLSSLTESAVGLEDKVNRTVVVSPVTGTVKTLYVNTVGGVIQPGMN
IIEIVPTEDTLLVEAQIAPQDIVFLRPDLPAIVKFSAYDFTRYGGLEGTLEHISADTTQD
EEGNSFYLVRVRTKETTLGHDQNLPIIPGMTASVDIITGKRTVLDYLLKPILSAQSNALR
E