Protein Info for CSW01_19440 in Vibrio cholerae E7946 ATCC 55056

Annotation: sodium/proline symporter PutP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 496 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 47 to 70 (24 residues), see Phobius details amino acids 75 to 92 (18 residues), see Phobius details amino acids 123 to 142 (20 residues), see Phobius details amino acids 160 to 182 (23 residues), see Phobius details amino acids 190 to 209 (20 residues), see Phobius details amino acids 234 to 254 (21 residues), see Phobius details amino acids 275 to 299 (25 residues), see Phobius details amino acids 314 to 338 (25 residues), see Phobius details amino acids 372 to 390 (19 residues), see Phobius details amino acids 401 to 421 (21 residues), see Phobius details amino acids 428 to 446 (19 residues), see Phobius details amino acids 456 to 474 (19 residues), see Phobius details TIGR02121: sodium/proline symporter" amino acids 6 to 490 (485 residues), 714.1 bits, see alignment E=8.5e-219 PF00474: SSF" amino acids 35 to 436 (402 residues), 359.1 bits, see alignment E=1.5e-111 TIGR00813: transporter, solute:sodium symporter (SSS) family" amino acids 35 to 436 (402 residues), 311.1 bits, see alignment E=1.3e-96

Best Hits

Swiss-Prot: 52% identical to PUTP_BACSU: High-affinity proline transporter PutP (putP) from Bacillus subtilis (strain 168)

KEGG orthology group: K11928, sodium/proline symporter (inferred from 100% identity to vco:VC0395_0171)

Predicted SEED Role

"Proline/sodium symporter PutP (TC 2.A.21.2.1) @ Propionate/sodium symporter" (TC 2.A.21.2.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (496 amino acids)

>CSW01_19440 sodium/proline symporter PutP (Vibrio cholerae E7946 ATCC 55056)
MENSFAITTTFIVYLILMLAIGVYAYQRTKNSADYFLGGRSLGPWPAALSAGASDMSGWL
LLGLPGYAYAAGIESFWLAGGLLVGTWANWLVNAKRLRTYSITTDSLTLPEFLSRRFNDN
SKLIQTISAFFILLFFLFYTSSGLVAGGKLFETVFGLDYSTAVIIGTVCVVSYTLFGGFL
AVSWTDLVQGLLMAAALMIVPIAAMNGGFTQLNHDLAAINPELLTLWNDAKGEPLSAIAI
ISLVAWGLGYFGQPHILARFKASRSNKDLITARRIAVVWTGLSMAGAILVGLTGLIFVTQ
SGTIGLDDGEKIFMLLVNSLFHPVIAGILLAAILAAIMSTADSQLLVSSSALAEDFYKQV
FKTDASSEDIVRVGRIAVILISLIALFLAMTPDSSVLGLVSYAWAGFGAAFGPALVLSLY
WPRMNRHGALSGIIVGGVTIVVWKQLSGGWFDVYEIVPGIILSTLSIVVVSLLTGEPDEK
VKAQHATFKKQLIELE