Protein Info for CSW01_19295 in Vibrio cholerae E7946 ATCC 55056

Annotation: phospho-sugar mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 567 PF02878: PGM_PMM_I" amino acids 41 to 181 (141 residues), 140.5 bits, see alignment E=6.1e-45 PF02879: PGM_PMM_II" amino acids 204 to 310 (107 residues), 89.5 bits, see alignment E=3.8e-29 PF02880: PGM_PMM_III" amino acids 322 to 441 (120 residues), 59.1 bits, see alignment E=9.2e-20 PF00408: PGM_PMM_IV" amino acids 508 to 536 (29 residues), 28.8 bits, see alignment (E = 2e-10)

Best Hits

KEGG orthology group: K01840, phosphomannomutase [EC: 5.4.2.8] (inferred from 100% identity to vco:VC0395_0200)

Predicted SEED Role

"Phosphomannomutase (EC 5.4.2.8)" in subsystem Alginate metabolism or Mannose Metabolism (EC 5.4.2.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.8

Use Curated BLAST to search for 5.4.2.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (567 amino acids)

>CSW01_19295 phospho-sugar mutase (Vibrio cholerae E7946 ATCC 55056)
MNSQVTHWLARDPDPKTRQELQQLIDTQQDAQIAERFQSRLEFGTAGLRGKVGCGPNRMN
RLVIQETAAGLGHYLIAQLPDAKSRGVVIGYDGRPDSKQFAHDTASVLTSLGIKTYLTYQ
VAATPIVAFGVRHFNAAAAVVVTASHNPPEYNGFKVYWENGAQIIPPHDAGIAACIDQAA
QQAIPYLALEQAEQQGLLHWLRDEYYQTYRKTIGASPLLQHHTKPQALSLAYTAMHGVGA
NMAETLLADVGFTHVSSVKEQREPDGTFPTVNFPNPEEAGAMDMVMALAKKVGAQLACAN
DPDADRFAVAARKADGEYQMLTGDQVGSLFGHYLLSQTDAHRQLVGNTIVSSSLLSKIAA
AHGARYYQTLTGFKWLTNVAMQEQTEQHQFLFAYEEALGYTIGSTVWDKDGLSALVAFAQ
LAAELNAQGKTVWDQLEALYRQHGLHVNAQRSIALDPNSPPVGDKLRATPPKDIAGRKVL
IVEDFKLARRTFADDKTETITLPTSDVLIYHLDGGARVIVRPSGTEPKLKCYYEVVTPFA
AGEDFVSAQERADEQMSLLIAEHQTSL