Protein Info for CSW01_19185 in Vibrio cholerae E7946 ATCC 55056

Annotation: 3-methyladenine DNA glycosylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 PF02805: Ada_Zn_binding" amino acids 12 to 75 (64 residues), 101.2 bits, see alignment E=5.1e-33 PF12833: HTH_18" amino acids 109 to 187 (79 residues), 81.2 bits, see alignment E=1.1e-26 PF06029: AlkA_N" amino acids 198 to 309 (112 residues), 129.1 bits, see alignment E=2e-41

Best Hits

KEGG orthology group: K13529, AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC: 3.2.2.21] (inferred from 100% identity to vco:VC0395_0222)

Predicted SEED Role

"ADA regulatory protein" in subsystem DNA repair, bacterial

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.2.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>CSW01_19185 3-methyladenine DNA glycosylase (Vibrio cholerae E7946 ATCC 55056)
MTLLNELSAEVCQRARMSRDPRFDGRFFVAVKTTGIFCRPICPANLPKEENVEYFSSQAL
AVSAGYRPCLRCRPESAPHSWAWKGAETTFLRALTLIEQGELDGSLETLASRLGISDRYL
RQLFQRHLGMPPKQYAQIQQLMFAKQLLHTSQISITEVAYASGFQSTRRFNDAFQKLFRL
TPTQVRRERAALPSRNHLSLAFRGPFDWAHMLDFYRLRAIEGMELIDEQSYQRHFVLGEG
TGWFKASMAQSHLDIEFEMERLSDLRHLVARLRRMFDLDADLISIEAHLEQLAPGLVRRT
GIRIPGVWNAWEAGVRAVLGQQVSVKAAIGQLNLLVSTLAASEGSTRYFPTPEQVQMSDL
SFLRMPERRKETLKRLADYVRLHPMDSPMAWLSLSGIGPWTVDYAQLRGESRSHCFLTGD
LIVKKALAKFPQLTAESVAPWGSYATFHCWSH