Protein Info for CSW01_19030 in Vibrio cholerae E7946 ATCC 55056

Annotation: L-lactate permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 582 transmembrane" amino acids 21 to 43 (23 residues), see Phobius details amino acids 49 to 66 (18 residues), see Phobius details amino acids 76 to 97 (22 residues), see Phobius details amino acids 122 to 141 (20 residues), see Phobius details amino acids 148 to 169 (22 residues), see Phobius details amino acids 217 to 241 (25 residues), see Phobius details amino acids 253 to 275 (23 residues), see Phobius details amino acids 281 to 300 (20 residues), see Phobius details amino acids 335 to 356 (22 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 422 to 441 (20 residues), see Phobius details amino acids 461 to 485 (25 residues), see Phobius details amino acids 503 to 536 (34 residues), see Phobius details amino acids 555 to 574 (20 residues), see Phobius details TIGR00795: transporter, lactate permease (LctP) family" amino acids 22 to 571 (550 residues), 353.1 bits, see alignment E=1.5e-109 PF02652: Lactate_perm" amino acids 25 to 565 (541 residues), 352.8 bits, see alignment E=1.8e-109

Best Hits

KEGG orthology group: K03303, lactate transporter, LctP family (inferred from 100% identity to vcm:VCM66_A0942)

Predicted SEED Role

"L-lactate permease" in subsystem Lactate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (582 amino acids)

>CSW01_19030 L-lactate permease (Vibrio cholerae E7946 ATCC 55056)
MRVSSSRLMESSRTRKYSMNETLLALVAFSPIVVAAILLVGLNWPAKKAMPVAFALTVAI
ALIFWDMSANRVIASVLQGLGITVSVLWIVFGAIFLLNTLKYTGAITTIRNGFTNISPDR
RVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPSLAAVLMGMMIQSTPVSFGAVG
TPIIVGVNKGLDTHNITEALLANGSNWDVYLQQITTSVALIHASVGTLMPILMAMMLTRF
FGKNRSWTEGLDILPFAIFSGLAFTVPYALTGVFLGPEFPSLMGGLVGLAIVVTAAKKGF
LVPKTQWDFRPENEWPAEWLGSLKMDLDDVKAKPMSLALAWAPYVLLAVILVASRVSADF
KALLLGIKVSFSHILGETGISTAIEPLYLPGGILVFVALIAVLTQARSLAPMVKAFGEST
KTLIGAGFVLVFTIPMVRIFINSGVNGADLASMPVTTANFAAGLVGEAFPMLSATVGALG
AFIAGSNTVSNMMFSQFQFEVAQTLTISSVVIIALQAVGAAAGNMIAIHNVVAASATVGL
LGREGATLRKTVLPTLYYLVLTGIIGMTVIYGFNMTDALMNR