Protein Info for CSW01_18990 in Vibrio cholerae E7946 ATCC 55056

Annotation: ATP-dependent protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 786 PF20437: LonC_helical" amino acids 87 to 120 (34 residues), 50 bits, see alignment (E = 4.6e-17) PF13654: AAA_32" amino acids 316 to 446 (131 residues), 169.6 bits, see alignment E=6.7e-54 PF20436: LonB_AAA-LID" amino acids 475 to 539 (65 residues), 79.1 bits, see alignment E=4.1e-26 PF05362: Lon_C" amino acids 649 to 752 (104 residues), 38.8 bits, see alignment E=1.6e-13

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_0263)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type II" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (786 amino acids)

>CSW01_18990 ATP-dependent protease (Vibrio cholerae E7946 ATCC 55056)
MAIQHLSFEQLYQVAKLEKLECKSTKELAPIDEIVGQERAQKAVEFAMSIKEKGYNIYAI
GRNGLGKRTMILRYLSRHQHDVNKLYDWCYVANFEDVRVPKVLKLPCGIGIQFRQDIEKL
MTKLVTAIPLAFDNEIYFSRAEKLKNQLAQKQESELESITRTAKERGVSLTLTPQGEYQF
VALNGEEMHTEETFDALSKREQEQFSNTIDELEVSLRNMVRQLTEWEESYSEKIKKLNDE
VTLDVIAHFIKKLKLDYSKYPEIKAYLTELQKDIVENVEIFLDEGADQGELANASLDKKM
PRRYKVNVLVSRNAEEFPIVVEESPNYHSLFGYIETATYKGTVFTDFSLIRPGSLHKANG
GVLLMDAVKVLEQPYVWDGLKRALRSRQLSFTSLEKEVTLTGTVSLDPEPIPLDVKIILF
GDYRTYELLAHYDPEFSELFRVTADFADEMPRDADSELHYARFISSIVHDANMLHCDRKA
IARIIEHSSRTTGDQTKLSLHSAHIANLLRESNYVAKQANANLIRQIHVEEALRNQELRV
NRLQQSMMETFVNGTTLIQTEGVAIGQVNALSVLATSDHAFGMPNRITATTSYGEGEIID
IERNVDLGGSIHSKGVMILSAYLSSVFGRTARIPLTTTITFEQSYGGVDGDSASMAEFCA
IVSAFSKQPNRQDIAITGSMNQFGESQPIGGLNEKIEGFFDVCTIKGRKDTQGVIIPRSN
MHNLMLRADVVKAVEKGEFHIWAIDHVTEAIEIFTGKPAGVATDDGSYPVDTVFGLAQAK
LNALRK