Protein Info for CSW01_18515 in Vibrio cholerae E7946 ATCC 55056

Annotation: DNA-binding transcriptional regulator DsdC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 314 TIGR02036: D-serine deaminase transcriptional activator" amino acids 10 to 311 (302 residues), 609.2 bits, see alignment E=5.3e-188 PF00126: HTH_1" amino acids 20 to 78 (59 residues), 77.6 bits, see alignment E=5.6e-26 PF03466: LysR_substrate" amino acids 101 to 309 (209 residues), 82 bits, see alignment E=4.2e-27

Best Hits

Swiss-Prot: 59% identical to DSDC_ECOLI: HTH-type transcriptional regulator DsdC (dsdC) from Escherichia coli (strain K12)

KEGG orthology group: K13636, LysR family transcriptional regulator, D-serine deaminase activator (inferred from 100% identity to vch:VCA0876)

Predicted SEED Role

"D-serine dehydratase transcriptional activator" in subsystem Glycine and Serine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (314 amino acids)

>CSW01_18515 DNA-binding transcriptional regulator DsdC (Vibrio cholerae E7946 ATCC 55056)
MYTKDNIFAKHSRINSFQLSKLHTFEVAARHNSFSLAADELSLTPSAISHRINKLEEEIG
IKLFERTHRKVVLTEEGQRIYHSLQKTLNNLNQEITDIKNGETSGLLTIYSRPSFAQCWL
VPRIHAFKELYPSIDLKLLTGNENISFQGSGIDVAIYFDDHMPDKLSCKEIFSETIIPVC
TPEYAQKYSLTSSMDNLYNTTLLHDNQAWNYNSDADEWKTWANANQLENLENISRIGFDR
SDLAVIAAINNAGIAMGRFSLVKSRLSSGELMTPYPNTEVICKQRYYVATLPNKHNQKVK
LFIDWLESQVKKAV