Protein Info for CSW01_18375 in Vibrio cholerae E7946 ATCC 55056

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 326 transmembrane" amino acids 20 to 43 (24 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 143 to 302 (160 residues), 115.9 bits, see alignment E=7.9e-38 PF00990: GGDEF" amino acids 146 to 299 (154 residues), 119.5 bits, see alignment E=6.2e-39

Best Hits

KEGG orthology group: None (inferred from 100% identity to vch:VCA0848)

Predicted SEED Role

"GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (326 amino acids)

>CSW01_18375 GGDEF domain-containing protein (Vibrio cholerae E7946 ATCC 55056)
MNDKVLESVIEITEQKNSLALSYSILATLSELLPLSTATLFHHLGRSTLMVARLIITKNA
AGKKEYQWQYDQVCADNGYQHSQSEMAFSQQANGQYQCFCPIPIEEHFSAELCLILNKDP
EPYRMLINGFAKIYRNYTVILHESERDKLTGLLNRRTLEDRLRHTFAINPSTEENHKLWI
AMLDIDHFKAINDHFGHMIGDEILLMFAQQMQHYFGPSSQLFRFGGEEFVIIFSSGNEPQ
IKQQLDGFRQQIRRHNFPRIGELSFSAGFCSLRPGDYLPTILDHADKALYYAKEHGRNQV
HCYEQLCENGKIASAQRPFSDDVELF