Protein Info for CSW01_18330 in Vibrio cholerae E7946 ATCC 55056

Annotation: drug/metabolite DMT transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 328 transmembrane" amino acids 24 to 44 (21 residues), see Phobius details amino acids 51 to 69 (19 residues), see Phobius details amino acids 81 to 102 (22 residues), see Phobius details amino acids 110 to 130 (21 residues), see Phobius details amino acids 137 to 155 (19 residues), see Phobius details amino acids 174 to 191 (18 residues), see Phobius details amino acids 202 to 220 (19 residues), see Phobius details amino acids 232 to 252 (21 residues), see Phobius details amino acids 260 to 282 (23 residues), see Phobius details amino acids 288 to 306 (19 residues), see Phobius details PF00892: EamA" amino acids 176 to 302 (127 residues), 35 bits, see alignment E=8.1e-13

Best Hits

Swiss-Prot: 45% identical to YDDG_SALT1: Methyl viologen resistance protein YddG (yddG) from Salmonella typhimurium (strain 14028s / SGSC 2262)

KEGG orthology group: None (inferred from 100% identity to vcm:VCM66_A0794)

MetaCyc: 45% identical to amino acid exporter YddG (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-265

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (328 amino acids)

>CSW01_18330 drug/metabolite DMT transporter permease (Vibrio cholerae E7946 ATCC 55056)
MIGREGVTTLRFTVKQQFITHKHTLYGVAAILLWGSLMALTRRVAEEFSPIGGAALIYTV
STLFLLFAMGMPRLKAGSSRYILIGGALFVSYEICLALALGMASDRLQAIEMSVINYLWP
ALTVLIAVLLSQRAVSFWVYPSVGLAFAGVAWTIVAEQGISLADFSARIATNPAVYAMAL
TGAFIWAIYCNVTQRLARGQNAIVLFFAATAATLWLQYALSNEPALSFTGSSMGTLLLTG
IVMGSGYALWNVAILRGNMLLLATLSYFTPVISTLFSSLILGVVLGLSFWQGVIMVTFGS
LICWWVTRESSSSTGEVPETPPPLKEQS