Protein Info for CSW01_18240 in Vibrio cholerae E7946 ATCC 55056

Annotation: mechanosensitive ion channel protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 194 transmembrane" amino acids 20 to 39 (20 residues), see Phobius details amino acids 60 to 80 (21 residues), see Phobius details amino acids 92 to 117 (26 residues), see Phobius details PF00924: MS_channel_2nd" amino acids 106 to 168 (63 residues), 27.6 bits, see alignment E=1.3e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to vcm:VCM66_A0776)

Predicted SEED Role

"Small-conductance mechanosensitive channel"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (194 amino acids)

>CSW01_18240 mechanosensitive ion channel protein (Vibrio cholerae E7946 ATCC 55056)
MSITVRYTMEYLALLQTHYKWLMTILIIVLYPHISRITLRLFESMLTGRVDIHRLKRARW
LIRTLLFLVMLFTTLILWGIELRGLLVVGSSLFALLGVGLFAGWSLLSNVTAFLILFVQN
QCRIGCWVRIVDGANFIEGKIIDMALLNVELETLEGNRVLYPNNLFIVRPVIVLQKAPEK
AVKKPERKQLPKGL