Protein Info for CSW01_18105 in Vibrio cholerae E7946 ATCC 55056

Annotation: isopentenyl-diphosphate delta-isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF20446: ABC_N
  • amino acids 1 to 152 (152 residues), 175.4 bits, E=1.3e-55
• PF09818: ABC_ATPase
  • amino acids 157 to 436 (280 residues), 432.7 bits, E=7.5e-134
• PF21117: MRB1590_C
  • amino acids 455 to 547 (93 residues), 48.6 bits, E=1.6e-16

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_0727)

Predicted SEED Role

"Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2)" in subsystem Archaeal lipids or Isoprenoid Biosynthesis or polyprenyl synthesis (EC 5.3.3.2)

MetaCyc Pathways

• methylerythritol phosphate pathway I (9/9 steps found)
• methylerythritol phosphate pathway II (9/9 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (11/12 steps found)
• isoprene biosynthesis I (9/10 steps found)
• taxadiene biosynthesis (engineered) (11/13 steps found)
• all-trans-farnesol biosynthesis (3/4 steps found)
• bisabolene biosynthesis (engineered) (3/6 steps found)
• mono-trans, poly-cis decaprenyl phosphate biosynthesis (2/5 steps found)
• mevalonate pathway I (eukaryotes and bacteria) (3/7 steps found)
• mevalonate pathway II (haloarchaea) (3/7 steps found)
• superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (5/10 steps found)
• isoprene biosynthesis II (engineered) (3/8 steps found)
• mevalonate pathway III (Thermoplasma) (3/8 steps found)
• mevalonate pathway IV (archaea) (3/8 steps found)
• superpathway of ergosterol biosynthesis II (11/26 steps found)
• superpathway of ergosterol biosynthesis I (5/26 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (9/33 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (24/56 steps found)
• superpathway of cholesterol biosynthesis (5/38 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.3.2

Protein Sequence (549 amino acids)

>CSW01_18105 isopentenyl-diphosphate delta-isomerase (Vibrio cholerae E7946 ATCC 55056)
MDRLIATLKKLEKQNYRAYQQIKGQYDFGDFTLFIDHIQSDPYASASRLRATRAWSLTGL
DWLKEKSPAYQMAARDFIARAFAEFAKQDNSLSIAISGQTVLDSTSVLFNEHGIELRFRM
SMPAEGRDILAKKALNILTFHLPKYIRRATLERELDKAALLHHCEIVEDQEAMRAQLDDL
GLVAFIANGSVLPRLAGNCDLPMKEAVPFIAPKSLEVTLSTPNQGELVGMGIPQGITLIV
GGGFHGKSTLLTALERSVYNHIPGDGRERMVTDVKAMKIRAEEGRCVHNLNLSNYINHLP
MGKDTTDFSTQDASGSTSQSAWLQESIEAGVTTLLIDEDTSATNFMIRDERMQALVSKGE
EPITPLVDRIGQLRDDLGISTLVVMGGSGDYLDVADTVIQMHDYQPVDVTEKAREVIAQH
PTLRRNECETPLATFTPRALNCATLQKLLLDGKFRVSAKGLDALRFGKEFTDISALEQLQ
SSSEVNAIGWLWFQLAQLPGWTDNPAKAMTKMLEGDWYQAMPNHGDLAKPRILDAMAALN
RMRKAQFKA