Protein Info for CSW01_17860 in Vibrio cholerae E7946 ATCC 55056

Annotation: autoinducer 2-binding periplasmic protein LuxP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 364 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF13407: Peripla_BP_4" amino acids 69 to 328 (260 residues), 59.6 bits, see alignment E=1.9e-20

Best Hits

Swiss-Prot: 100% identical to LUXP_VIBCH: Autoinducer 2-binding periplasmic protein LuxP (luxP) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K10910, autoinducer 2-binding periplasmic protein LuxP (inferred from 100% identity to vco:VC0395_0673)

Predicted SEED Role

"Autoinducer 2-binding periplasmic protein LuxP precursor" in subsystem Autoinducer 2 (AI-2) transport and processing (lsrACDBFGE operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (364 amino acids)

>CSW01_17860 autoinducer 2-binding periplasmic protein LuxP (Vibrio cholerae E7946 ATCC 55056)
MKRKLISPLFLIAALFSSTGQADSLKGYWHYDEFLAEFPEQRPISELFAQTVRDKPSALT
VAQEQPVIISVVYPGQQISDYWVRNIKAFEKRMDALGIRYQINQVFTRPNLDTRQQSVSL
MEALKNKSDYLIFTLDTTRHRKFIEHVLHSSETKLILQNITTPVKDWQGKQPMMYIGFDH
EYGAQLLAQYYQAHAPKKPYSVLYFSEGYISEARGDTFIQDMNAVHHFPLASSYYTKATE
QSGYEATLNIVKNNPEIGFIYACATDVALGAAQALKELNRQDILVNGWGGGSAELEALAK
GELDVTVMRMNDDTGVAMAEAIKWDLEGKSVPLVYSGDFEVVTKQDSAARIAELKARAFR
YSDR