Protein Info for CSW01_17855 in Vibrio cholerae E7946 ATCC 55056

Annotation: autoinducer 2 sensor kinase/phosphatase LuxQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 857 transmembrane" amino acids 14 to 36 (23 residues), see Phobius details amino acids 281 to 303 (23 residues), see Phobius details PF09308: LuxQ-periplasm" amino acids 41 to 277 (237 residues), 344.1 bits, see alignment E=8.9e-107 PF00512: HisKA" amino acids 480 to 544 (65 residues), 74.6 bits, see alignment 1.1e-24 PF02518: HATPase_c" amino acids 592 to 705 (114 residues), 100.5 bits, see alignment E=1.5e-32 PF00072: Response_reg" amino acids 732 to 842 (111 residues), 78.6 bits, see alignment E=8.1e-26

Best Hits

Swiss-Prot: 100% identical to LUXQ_VIBCH: Autoinducer 2 sensor kinase/phosphatase LuxQ (luxQ) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K10909, two-component system, autoinducer 2 sensor kinase/phosphatase LuxQ [EC: 2.7.13.3 3.1.3.-] (inferred from 100% identity to vcj:VCD_000584)

Predicted SEED Role

"Autoinducer 2 sensor kinase/phosphatase LuxQ (EC 2.7.3.-) (EC 3.1.3.-)" in subsystem Autoinducer 2 (AI-2) transport and processing (lsrACDBFGE operon) (EC 2.7.3.-, EC 3.1.3.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-, 3.1.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.- or 3.1.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (857 amino acids)

>CSW01_17855 autoinducer 2 sensor kinase/phosphatase LuxQ (Vibrio cholerae E7946 ATCC 55056)
MNIRPSQIKHKQRIASFITHAVVVVMGVLIVSVLFQSYQISSRLMAQEGQRTSVQTSSLI
QSLFDFRLAALRIHQDSTAKNASLINALVSRDSSRLDEFFSSVDELELSNAPDLRFISSH
DNILWDDGNASFYGIAQQELNKLIRRVAISGNWHLVQTPSEGKSVHILMRRSSLIEAGTG
QVVGYLYVGIVLNDNFALLENIRSGSNSENLVLAVDTTPLVSTLKGNEPYSLDYVVHSAK
DAMRDSFIVGQTFLEVESVPTYLCVYSIQTNQNVLTLRDNFYFWMAFALISMIGVSIASR
WWLQKRIQREIETLMNYTHKLMDLDTKSEFIGSKIYEFDYFGRTLEQSFRRLANKEKQFE
DLFNFALSPTMLWNTSGRLIRMNPSAQIQFLREDAQNHFLFEILERQLLPTITNAAQGNN
PSDVTTEVDGRVYRWNLSPIMVEGQIISIITQGQDITTIAEAEKQSQAARREAEESARVR
AEFLAKMSHELRTPLNGVLGVSQLLKRTPLNDEQREHVAVLCSSGEHLLAVLNDILDFSR
LEQGKFRIQKNEFRLKELVCAIDRIYRPLCNEKGLELVVNSNITTAAIVRSDQIRINQIL
FNLLNNAIKFTHQGSIRVELQLIEGDPLAQLVIQVVDTGIGIREQDLTVIFEPFMQAEST
TTREYGGSGLGLTIVHSLVEMLSGQLHVSSEYGIGTRFEIQLPIELVEKPDAPQQLLPAP
DPQPLFDKTLRVLLVEDNHTNAFIAQAFCRKYGLDVSWVTDGLQAIEELKIHDYDLVLMD
NQLPYLDGVETTRTIKKVLHLPVVVYACTADGLEETRQAFFHAGAEYVLVKPLKEQTLHK
ALEHFKHHHGQKNAGLN