Protein Info for CSW01_17810 in Vibrio cholerae E7946 ATCC 55056

Annotation: cobyric acid synthase CobQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 484 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF13500: AAA_26" amino acids 5 to 229 (225 residues), 69.5 bits, see alignment E=5.4e-23 PF01656: CbiA" amino acids 5 to 230 (226 residues), 79.2 bits, see alignment E=4.1e-26 TIGR00313: cobyric acid synthase CobQ" amino acids 5 to 479 (475 residues), 523.9 bits, see alignment E=2.1e-161 PF07685: GATase_3" amino acids 251 to 436 (186 residues), 191.8 bits, see alignment E=1.6e-60

Best Hits

Swiss-Prot: 100% identical to COBQ_VIBCH: Cobyric acid synthase (cobQ) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 100% identity to vcj:VCD_000592)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (484 amino acids)

>CSW01_17810 cobyric acid synthase CobQ (Vibrio cholerae E7946 ATCC 55056)
MKKWLMVQGTTSDAGKSVLVAGLCRVLARRGIQVCPFKPQNMALNSAVTPDGGEIGRAQA
VQAQACGIAPSVHMNPVLLKPNSDTGAQVILQGRALSNMEANAYHDYKKVAMDTVMDSFQ
RLQQEYEAIMIEGAGSPAEINLRENDIANMGFAEKADVPVIIVADIDRGGVFAHLYGTLA
LLSESEQARVKGFVINRFRGDIGLLQSGLDWLEQKTGKPVIGVLPYLHGFDLEAEDAIAA
QQNLSADRQLRVAVPVFTRISNHTDFDPLRLNPNIDFRYVGQGESLSGADLIILPGSKST
RADLAYLRSQGWDKEILRHLRLGGKVMGICGGFQMLGEWVHDPLGIEGEAGSSEGLGLFA
MQTELTAEKRLTNVKGHLTLDGQTVAAQGYEIHAGHSSWAADQKSPIILSDGSLDGLVSD
CNQGFGTYLHGIFDRPETALRICQWAGAKEIEAYDHRAAQERAIDRIADAIEQHLDLTLL
WPDL