Protein Info for CSW01_17760 in Vibrio cholerae E7946 ATCC 55056

Annotation: DNA helicase IV

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 687 PF12462: Helicase_IV_N" amino acids 1 to 166 (166 residues), 188.9 bits, see alignment E=2.2e-59 PF00580: UvrD-helicase" amino acids 200 to 496 (297 residues), 174.4 bits, see alignment E=1.4e-54 PF13245: AAA_19" amino acids 204 to 481 (278 residues), 79.4 bits, see alignment E=1e-25 PF13361: UvrD_C" amino acids 594 to 666 (73 residues), 59.4 bits, see alignment E=1.5e-19

Best Hits

KEGG orthology group: K03658, DNA helicase IV [EC: 3.6.4.12] (inferred from 100% identity to vco:VC0395_0656)

Predicted SEED Role

"DNA helicase IV" in subsystem DNA repair, bacterial UvrD and related helicases

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (687 amino acids)

>CSW01_17760 DNA helicase IV (Vibrio cholerae E7946 ATCC 55056)
MQLNANKTAQFFIANEYYQVQLEKEWLVLTSLSSEERIPFHVWNGEVQIRRGVFWGTLQF
FAHPEEGVQRSWLVQGLPWPECRHFAHQLVAHYQAWHNRQCEQLSLYFPRWQQELSRLKR
LPSFLSHSSVEAWVAQVYADLKLMDMTLHEAQKHLPTVFDTLLPWLLDTSATLYERNKAW
LEIERANWTVLFSQCESSPLNVSQQYAVLLNDDHNLVLAGAGSGKTSVLTARVSYLLQSH
LAKPEQILLVAFARDAAQEMAERLKNKIGLEAERLHINTFHQLGLRIINRVEGKTVIMSP
LANDSKLKQAWCIDWLKRHWMTPTNFKRWQKHLAKWPIAYLAGDDELGSHVENPKLIAWL
EKQLDQLAQMGLSKKELQERLVDHDDYPRLNSELSLCWPCYQAWQQMLKDQNQIDFNIMI
TRATEYVEKGKFRSPWKFIMVDEYQDISPQRLRLLQALCEQNQGQCNLFAVGDDWQSIYQ
FAGSDVDLTTGFASRFAHSTVHHLDTTYRFNDQIGAVANRFIQQNPHQLPKTLNSFKTQK
QKAVMLAPNHSVEKILDEINRSTNKLKTVLLLGRNHYHKPELLKDWQNRYLSLKLDFMTC
HASKGKEADYVIILAVDEGQFPARVKALHLDDALNQSEDDFPYAEERRLFYVALTRAKEK
VWVTYNGNGSSFVQELLNDDYPVVKQK