Protein Info for CSW01_17725 in Vibrio cholerae E7946 ATCC 55056

Annotation: TMAO reductase system sensor histidine kinase/response regulator TorS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 984 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 336 to 357 (22 residues), see Phobius details TIGR02956: TMAO reductase sytem sensor TorS" amino acids 7 to 980 (974 residues), 1431.6 bits, see alignment E=0 PF21689: TorS_sensor_domain" amino acids 49 to 322 (274 residues), 378.2 bits, see alignment E=7.8e-117 PF00672: HAMP" amino acids 358 to 405 (48 residues), 27.4 bits, see alignment 1e-09 PF00512: HisKA" amino acids 469 to 534 (66 residues), 75.7 bits, see alignment 6.9e-25 PF02518: HATPase_c" amino acids 581 to 692 (112 residues), 107.7 bits, see alignment E=1.3e-34 PF00072: Response_reg" amino acids 712 to 826 (115 residues), 65.5 bits, see alignment E=1.4e-21 PF01627: Hpt" amino acids 897 to 972 (76 residues), 39.6 bits, see alignment 1.6e-13

Best Hits

KEGG orthology group: K07647, two-component system, OmpR family, sensor histidine kinase TorS [EC: 2.7.13.3] (inferred from 100% identity to vch:VCA0709)

Predicted SEED Role

"Sensor protein torS (EC 2.7.3.-)" in subsystem trimethylamine N-oxide (TMAO) reductase (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (984 amino acids)

>CSW01_17725 TMAO reductase system sensor histidine kinase/response regulator TorS (Vibrio cholerae E7946 ATCC 55056)
MRLAKASIGRKLLFSFSAMALLVLLSALIGVLGFSLVAKTERDVVNNAIPSMIEARQVAE
LSHQIIASVQTLSNAKNEQEHQAAGQKVFSQLETLLTHIQQLGEEAFDSVLLDRLEQDVQ
NVIDTLAQLGRRVEHRLTLESQLSTSVKEMRKLAQELEQLTRTQVLNTSTIAIANVTHIY
DLLQKQQQAQVYQALDNLVEVDLDLAERLHELHLLAFKVLNEIEETQTVTDLERILALDS
EFAANLSIMQRRVQAVEDPTRSKQMVSLLRGLEKRRIVFELLKQRYSNEQAAQQLLHDTL
TQFAKLNNTVNQLVDASNQVTTAAVSKLSNTLYDAQLILTVLGLLGLVIVVWIVWKVVYR
SVIQRLDQHTAALLSVAKGQLDVDVSTQGNDELGQMGQAIAHARDTAKALKVVAESEVLA
KRELQQHKEHLEELVEQRTCQLSEMNHKLNQEVLNHAKARQQAEQASRAKSAFLATMSHE
IRTPMNGVLGTARLLQDTTLTSTQQHYVQVINRSGRSLLAILNDVLDYSKIEAGHLEIHH
THFDLYRLVSETHELMQSRAREKGITLTYHIDEDVTQYWQGDEIRIGQVLNNLVGNGIKF
TDQGEVRIRIRLAPDGQGIRFAVEDSGIGIAEEEQATLFDAFTQADAGRRKLGGTGLGLA
ISRKLVQAMGGELQLASQLGQGSCFWFTLPLPVGEPVETPALAVDDVPVANVLLVEDNEV
NCLVAQGFLTSLGHQVTLAKSVQEAKLCFQQQRFDIALLDIHLPDGNGVDLLRDLRQMED
SIHNAVIPFIAVSAHVFNEEVAGYLAAGFDGYLPKPLVKEQLAAMLRQQLTAKSGDDADM
RDKAESHDTSSIFDNGQPQGEPSPEAQAVRKEWVAVMDHAKFEQDVQILGVEKMREIVGY
FEQGCAEFFALCEAERDNDAQIKSQAHKLKGSAGALWLTQLYQLCQQIEKADSPAAAYQQ
TPLVDAVENAKQALRNALDLLSKE