Protein Info for CSW01_17705 in Vibrio cholerae E7946 ATCC 55056

Annotation: two-component sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 789 signal peptide" amino acids 9 to 12 (4 residues), see Phobius details transmembrane" amino acids 13 to 33 (21 residues), see Phobius details amino acids 322 to 342 (21 residues), see Phobius details PF00672: HAMP" amino acids 341 to 383 (43 residues), 30.3 bits, see alignment 6.7e-11 PF00512: HisKA" amino acids 566 to 630 (65 residues), 35.2 bits, see alignment E=1.6e-12 PF02518: HATPase_c" amino acids 675 to 781 (107 residues), 68.6 bits, see alignment E=9.2e-23

Best Hits

KEGG orthology group: K08475, two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC: 2.7.13.3] (inferred from 100% identity to vcm:VCM66_A0663)

Predicted SEED Role

"Phosphoglycerate transport system sensor protein PgtB (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (789 amino acids)

>CSW01_17705 two-component sensor histidine kinase (Vibrio cholerae E7946 ATCC 55056)
MSLTTRHTIGARLLLAFAFSTSLLTIVSLVAWGTWSRLDYQVAELLNQSVPKYNTSYVLE
TRSSEIRRRIQLIVSATSKVTLNQQYQRLQEDFTAIHAALASLPQNEQQAALQQGYTELR
QTTQQINDLVSARIDVDRRLALFAEQLDWLHQDIGMELSPMRQELQWQLERGGAAQPQAQ
VMFQTINLIQTILDGETQAFLFVDELLKAKHLTQVDNGMRVLQYRLDELSRLSQPLFTQP
SSIAYQQLLEEWRNVLRLEGDFQQSLRDRVVLTQKLESTSEQLQIQLDQQHTAIADLVAN
ADALFVQVKGQTAQLVQEGNRVLLICFGLSIGLSLLLMYYFVHKRIVGRLHRLSESLDAI
IHNDLSHPITVDGKDEIGALSEQLILYGKKVEEMERTNALSLINNTQASLITCDRYGQIE
SANPSAMATLRLESLAQPLTLWSCFAKHVQPKVGQLFDKKGNLIQKGAESLTLSLGNPEK
PHYLRLYLRRYSQGLHDKIIVTITDVTDQEHANRLLEQRVKEKTQSLREKNRELQAEVEE
RQRAEAHLKKTQGELIQAAKMAVVGQTMTSLAHELNQPLSAMSAYLFSARLALEEAPQAQ
LATSLDHIENLTERMGKIVNSLRHFARKNSSDESLQPVRLNSVVEQALVLVQTKAKRQQI
KLINTLPDDLMVMADALSLEQVLINLIVNGCDASTTFAQPWVKLIALGTEQGMQRIAVID
SGQGFEHEVVDKLFTPFTTTKEVGLGLGLSICQSLVEKMQGRIALASNLEKGAMVILELQ
QDEKYRTAD