Protein Info for CSW01_17700 in Vibrio cholerae E7946 ATCC 55056

Annotation: sigma-54-dependent Fis family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 439 PF00072: Response_reg" amino acids 24 to 133 (110 residues), 91.5 bits, see alignment E=7.8e-30 PF00158: Sigma54_activat" amino acids 158 to 213 (56 residues), 27.8 bits, see alignment 3.7e-10 PF14532: Sigma54_activ_2" amino acids 159 to 305 (147 residues), 59.3 bits, see alignment E=1e-19 PF02954: HTH_8" amino acids 389 to 428 (40 residues), 29.6 bits, see alignment 9.6e-11

Best Hits

KEGG orthology group: K08476, two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA (inferred from 100% identity to vcm:VCM66_A0662)

Predicted SEED Role

"Phosphoglycerate transport system transcriptional regulatory protein PgtA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (439 amino acids)

>CSW01_17700 sigma-54-dependent Fis family transcriptional regulator (Vibrio cholerae E7946 ATCC 55056)
MHWPLIWKKVQWLFWSYSKMKSTVLLIDDDQDVLDSYLHLMSIAGLTAKAVIDPTQAMSH
IQPDWNGVVLLDMYMPQLHGMELLKQIKAVDDKIPVIVITGHGDIPMAVEAVKMGACDFL
EKPINPPQLLTLIKQHLELRRSFIEQKLLLSRSVKRELVGKSAQMEQIRSHVAQYALLNR
HVVIVGESGCGRHTIAYLIHQLTTNNGHLPWVELVASAKTEWSTVEPKVQESAGGTLLID
HIELLSEEVQRNVVQSLLNQERLNRPRTRVIAVIDQPPEQLIAQNQLLPELYYLLNQGQI
DVPLLRQRPDDIAALFHYFLKQSCYKLGKPMPNVEPHYLALLRAHQWPGNVRELRNVAEL
YAIGIVKLAGKERLYNQEEMLSPLDELVDDYEKQVIEDALFLFSGRVADAANYLQVPRKK
LYLRMKKHGLEKDAFKARG