Protein Info for CSW01_17620 in Vibrio cholerae E7946 ATCC 55056

Annotation: iron(III) ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 344 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF13531: SBP_bac_11" amino acids 31 to 290 (260 residues), 57.9 bits, see alignment E=2.8e-19 PF01547: SBP_bac_1" amino acids 44 to 284 (241 residues), 42 bits, see alignment E=2.5e-14 PF13416: SBP_bac_8" amino acids 46 to 306 (261 residues), 69.9 bits, see alignment E=6.7e-23 PF13343: SBP_bac_6" amino acids 95 to 319 (225 residues), 93 bits, see alignment E=4.2e-30

Best Hits

Swiss-Prot: 69% identical to Y131_HAEIN: Uncharacterized protein HI_0131 (HI_0131) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K02012, iron(III) transport system substrate-binding protein (inferred from 100% identity to vco:VC0395_0625)

Predicted SEED Role

"Ferric iron ABC transporter, iron-binding protein" in subsystem Campylobacter Iron Metabolism or Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (344 amino acids)

>CSW01_17620 iron(III) ABC transporter substrate-binding protein (Vibrio cholerae E7946 ATCC 55056)
MIVNAKRTLLALSVLGSMMTAPLVHAEGRLVVYCSATNAMCEAGTKAFAEKYNVNTSFVR
NGSGSTLAKIDAEKNNPRADVWYGGTLDPQSQAGEMDLLQAYQSPELANIMEGFRDPAKR
KGNYSSAVYMGILGFGVNTERLAQKGIPIPRCWADLTKPEYKGEIQISDPQSSGTAYTAL
ATFIQLWDEPTAFEYFKKLDKNVSQYTKSGVTPSRNSARGEVAIGIGFLHDYSLEQAKGA
PLELISPCEGTGYELGGVSIIKGARNLDNAKLFVDWVLSKEGQEVAWKQGDSYQILTNTQ
AEQSPNALDPKTLKLINYDMETYGSSDERKRLITKWVNEIKMGN